Publications by authors named "Gaia Macaluso"
Article Synopsis
- Oxidative stress happens when antioxidants can't keep up with reactive oxygen species, leading to DNA damage and health issues, like ARSACS, a neurodegenerative disease caused by mutations in the sacsin gene.
- Cells from ARSACS patients show energy and mitochondrial problems, requiring treatments capable of crossing the blood-brain barrier for effective delivery.
- The study focuses on nanostructured lipid carriers (NLCs) loaded with idebenone, a compound that fights oxidative stress, showing stability and potential effectiveness in targeting ARSACS while demonstrating the ability to cross a blood-brain barrier model.
