Publications by authors named "Gaia Biscalchin"
Article Synopsis
- Tuberous sclerosis complex (TSC) causes issues like drug-resistant epilepsy and intellectual disabilities due to abnormal cortical structures like cortical tubers.
- * The study aimed to investigate the gyrification index (GI) as a potential indicator of TSC severity, analyzing MRI data of 45 TSC patients and 42 healthy controls.
- * Results showed that TSC patients had a higher GI, which correlated with neurological impairments, epilepsy, and other disorders, suggesting GI could serve as a valuable prognostic tool for characterizing TSC.
We report the case of a previously healthy newborn who developed super-refractory status epilepticus after Group B streptococcal meningoencephalitis. After administration of first-, second- and third-line anticonvulsants without resolution of status epilepticus, we started intravenous lacosamide as adjunctive therapy to phenobarbital, phenytoin and continuous infusion of ketamine and midazolam. After administration of lacosamide, we observed a clear-cut improvement in the neurological clinical condition coupled with seizure control on continuous video-EEG monitoring, even after suspension of all other medications except for phenobarbital.
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