Publications by authors named "Gaia Bianchi"
Feline injection-site sarcomas (FISSs) are malignant skin tumors of mesenchymal origin arising at local post-vaccination (or injection) sites. In recent years, a fluorescence imaging technique based on probes targeting αβ integrin has been effectively applied for the surgical complete resection of the tumor. In our study, we investigated the utility of a commercially available anti-α integrin polyclonal antibody for the histopathological evaluation of FISS's surgical excision margins.
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- Macrophages play a crucial role in the immune response within the tumor environment of colorectal cancer (CRC), and their unique properties can be harnessed to create targeted nanoparticles for treatment.
- Lipid nanovesicles (LNVs) were developed using membrane proteins from differentiated THP-1 cells, resulting in two types: T-LNVs and M1-LNVs, both loaded with the cancer drug doxorubicin (DOXO).
- M1-LNVs demonstrated greater effectiveness in targeting and killing cancer cells compared to T-LNVs, showing promise for precision medicine in cancer therapy with reduced side effects.
Extracellular vesicles (EVs) are membranous cargo particles that mediate intercellular communication. They are heterogeneous in size and mechanism of release, and found in all biological fluids. Since EV content is in relation to the originating cell type and to its physiopathological conditions, EVs are under study to understand organ physiology and pathology.
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