Publications by authors named "Gai Y"

Microplastics (MPs) recycling, a promising approach to tackle its pollution, faces significant challenges due to the lack of effective separation methods. Herein, the optimized density separation accompanied with nonionic surfactants was employed to purify single MPs species from mixed systems. By adjusting the flotation fluid density, the single MPs can be separated from their mixtures in equal proportions (e.

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Skull defects are common in the clinical practice of neurosurgery, and they are easily complicated by encephalitis, which seriously threatens the life and health safety of patients. The treatment of encephalitis is not only to save the patient but also to benefit the society. Based on the advantages of injectable hydrogels such as minimally invasive surgery, self-adaptation to irregularly shaped defects, and easy loading and delivery of nanomedicines, an injectable hydrogel that can be crosslinked in situ at the ambient temperature of the brain for the treatment of encephalitis caused by cranial defects is developed.

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Background: Rumen methane emissions (RMEs) significantly contribute to global greenhouse gas emissions, underscoring the essentials to identify effective inhibitors for RME mitigation. Despite various inhibitors shown potential in reducing RME by modulating rumen microbes, their impacts include considerable variations and inconsistency.

Objectives: We aimed to quantitatively assess the impacts of various methane inhibitors on RME, rumen microbial abundance, and fermentation in ruminants.

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Background: The incidence of dyslipidemia as a risk factor for many serious diseases is increasing year by year. This study aimed to construct and visualize a risk prediction model for dyslipidemia in middle-aged and older adults.

Method: The subjects of our study are derived from CHARLS.

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Purpose: Noninvasive angiogenesis visualization is essential for evaluating tumor proliferation, progression, invasion, and metastasis. This study aimed to translate the heterodimeric PET tracer [Ga]Ga-HX01, which targets integrin αvβ3 and CD13 in neovascularization, into phase I clinical study.

Methods: This study enrolled 12 healthy volunteers (phase Ia) and 10 patients with malignant tumors (phase Ib).

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Purpose: Radiolabeled probes targeting prostate-specific membrane antigen (PSMA) have been used in prostate cancer. Moreover, PSMA is also overexpressed on neovessels in hepatocellular carcinoma (HCC). This study aimed to preliminarily evaluate the diagnostic effectiveness of [Ga]Ga-PSMA-617 PET/MRI for HCC.

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Our fingers are the most dexterous and complicated parts of our body and play a significant role in our daily activities. Non-invasive techniques, such as Electroencephalography (EEG) and Electromyography (EMG) can be used to collect neural and muscular signals related to finger movements. In this study, we combined an 8-channel EMG and a 31-channel EEG while the human subject moved one of the five fingers on the right hand.

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Article Synopsis
  • MAZ is found to have increased expression in melanoma, which is linked to worse prognosis for patients.
  • MAZ contributes to melanoma’s aggressive behavior by promoting cell growth, movement, and invasion.
  • The study identifies MAZ's role in regulating NDUFS3, a key mitochondrial protein, suggesting that the levels of MAZ and NDUFS3 together could be used as a predictive marker for melanoma prognosis.
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The article proposes a novel state-feedback control method for a multiple-input multiple-output (MIMO) nonlinear system with actuator faults and input quantization. The innovation of the design approach lies in the utilization of fuzzy logic systems (FLSs) to approximate the uncertain intermediate virtual control laws, thereby achieving a simplified virtual control design form. Additionally, finite-time control is employed to enhance the system's response speed.

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The decline in biodiversity poses a serious threat to natural ecosystems and has become one of the most pressing global environmental issues. Establishing conservation priorities for protected areas (PAs) is one of the most direct and effective biodiversity conservation measures. However, conservation gaps arise as a result of existing problems in spatial layout of PAs, including overlapping protection scopes, artificial fragmentation of natural ecological regions, as well as "over-protection" and "over-exploitation.

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Traumatic death is a risk factor for prolonged grief. Network analysis offers a perspective for understanding traumatic bereavement at a symptom interaction level. This study estimates regularized partial correlation grief networks for bereavement due to earthquake (n = 818) and illness (n = 237), using symptoms from the Inventory of Complicated Grief (ICG) as the nodes.

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Because of the insidious nature of lymphatic metastatic cancer, accurate imaging tracing is very difficult to achieve in the clinic. Previous studies have developed the LARGR peptide (named TMVP1) as a radiotracer for vascular endothelial growth factor receptor-3 (VEGFR-3) imaging in cancer. However, its affinity for the target remains insufficient, resulting in low imaging sensitivity.

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Social support can promote posttraumatic growth (PTG) in the general trauma population. However, evidence on the reciprocal predictive relationship between social support and PTG is lacking, particularly among the bereaved. In this longitudinal study, we surveyed 181 adults who had lost first-degree relatives within 1 year at three intervals, each 6 months apart.

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Record-breaking hot weather (exceptional heatwaves) has been increasingly common worldwide, posing a significant threat to human health. However, little is known about the effect of these exceptional heatwaves on mortality in Europe, especially since the coronavirus disease 2019 (COVID-19) outbreak, which converges with climate change to affect healthcare systems and human lives. We collected mortality data of 967 regions in 30 European countries over the last decade (2014-2023) from the Eurostat.

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Purpose: This study aimed to describe and evaluate a real-time ultrasound-guided (US-guided) drainage technique for effective and safe drainage of gas-forming renal abscesses (GRA) in an intensive care unit(ICU).

Materials And Methods: This retrospective study included four patients with GRA who were admitted to the ICU of a tertiary care center between September 2021 and September 2023. The patients were all comorbid with severe systemic infections and required drainage of abscesses for infection control.

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Article Synopsis
  • - NOD2 is an important immune sensor that has a tumor-suppressive effect in melanoma by inhibiting cell proliferation, migration, and invasion while promoting apoptosis.
  • - The study found that NOD2 regulates thymidylate synthase (TYMS) expression through a specific ubiquitination process, which makes melanoma cells more sensitive to chemotherapeutic drugs like 5-fluorouracil (5-FU) and capecitabine (CAP).
  • - Additionally, the research indicates that combining a PLK1 inhibitor (volasertib) with these chemotherapy drugs can work synergistically to further enhance the suppression of melanoma cell growth and migration.
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  • * Liver diseases often have a slow progression, are hard to treat, and current therapies are ineffective, leading to lasting liver damage and the need for deeper understanding of their molecular mechanics.
  • * MicroRNA (miR-22) is emerging as an important player in liver disease, regulating metabolic processes and offering potential for early diagnosis and targeted treatment, making it a focus for future research.
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Background: Diabetic nephropathy (DN) is the most frequent chronic microvascular consequence of diabetes, and podocyte injury and malfunction are closely related to the development of DN. Studies have shown that corilagin (Cor) has hepatoprotective, anti-inflammatory, antibacterial, antioxidant, anti-hypertensive, anti-diabetic, and anti-tumor activities.

Aim: To explore the protective effect of Cor against podocyte injury in DN mice and the underlying mechanisms.

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The transcription factor Ethylene Responsive Factor (ERF) is crucial for responding to various environmental stressors. Proteins containing the ERF-associated amphiphilic repression (EAR) motif often inhibit gene expression. However, the functions of LkERF, an EAR motif-containing protein from Larix kaempferi, especially in reactive oxygen species (ROS) homeostasis, are not well understood.

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Currently, nearly 70% of giant panda populations are facing survival challenges. The introduction of wild individuals can bring vitality to them. To explore this possibility, we hypothetically introduced giant pandas from Tangjiahe and Wanglang into Liziping and Daxiangling Nature Reserves.

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A study on DPC and iDPC images of crystals is achieved with simulation. It highlights the use of electron wave intensity distribution to visualize the dynamic effect on DPC and iDPC contrasts. Electron waves near heavy atoms exhibit significant oscillations and rapid intensity decay.

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The adventitious root formaton (ARF) in excised plant parts is essential for the survival of isolated plant fragments. In this study, we explored the complex mechanisms of ARF in Larix kaempferi by conducting a comprehensive proteomic analysis across three distinct stages: the induction of adventitious root primordia (C1, 0-25 d), the formation of adventitious root primordia (C2, 25-35 d), and the elongation of adventitious roots (C3, 35-45 d). We identified 1976 proteins, with 263 and 156 proteins exhibiting increased abundance in the C2/C1 and C3/C2 transitions, respectively.

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  • * JOSD1 has been identified as a key deubiquitinase that influences Hippo signaling and colon cancer progression, where its inhibition can slow tumor growth.
  • * Research shows that JOSD1 not only activates Hippo signaling by preventing YAP degradation but also promotes its own expression through a positive feedback loop, indicating a complex relationship in colon cancer dynamics.
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Background/aims:  Accumulating evidences have shown an important role of circular RNAs (circRNAs) in the tumorigenesis of gastric cancer (GC). Nevertheless, whether circSNX27 plays a role in GC remains undetermined.

Materials And Methods:  Relative expression of circRNAs and related microRNAs (miRNAs) in GC tissues and cells were tested by quantitative reverse transcription polymerase chain reaction.

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  • The study aimed to evaluate the effectiveness of an early rehabilitation program for VV-ECMO patients and its impact on respiratory and skeletal muscle function.
  • Conducted in a comprehensive ICU, the research included measurements of various muscle parameters on multiple days after treatment for both a control group (usual rehab) and a study group (early rehab).
  • The findings suggested that early rehabilitation led to less muscle atrophy and a shorter ECMO duration, indicating potential benefits of this approach for VV-ECMO patients.*
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