Screening of intracerebral hemorrhage associated allele combinations at different loci using a novel association analysis.

Background: Genetic research has progressed along with scientific and technological developments. However, it is difficult to identify frequency differences in the allele combination at cross-loci.

Objective: The purpose of this study was to examine the relationship between the presence of specific allele combinations of short tandem repeat (STR) loci and the onset of intracerebral hemorrhage (ICH) using a novel methodology.

Distributions of allele combination in single and cross loci among patients with several kinds of chronic diseases and the normal population.

Genetic research has progressed along with scientific and technological developments. However, it is difficult to identify frequency differences in a particular allele distribution at a single locus. Such differences can be identified by examining the allele combination distribution.

A new design without control population for identification of gastric cancer-related allele combinations based on interaction of genes.

Objective: The purpose of this study was to develop a novel approach without control population to examine the relationship between the presence of specific allele combinations at different loci with the onset of gastric cancer.

Methods: DNA samples were collected from patients with gastric cancer. Alleles from short tandem repeat loci were determined using the STR Profiler Plus PCR amplification kit (15 STR loci).

Statistical estimation of diagnosis with genetic markers based on decision tree analysis of complex disease.

To explore combinations of genetic markers and to estimate their joint action, decision trees are built on the basis of marker frequencies in both disease and control groups. Youden's index (0.1-0.