Ethanol Exposure to Ethanol-Oxidizing HEPG2 Cells Induces Intracellular Protein Aggregation.

Background: Aggresomes are collections of intracellular protein aggregates. In liver cells of patients with alcoholic hepatitis, aggresomes appear histologically as cellular inclusions known as Mallory-Denk (M-D) bodies. The proteasome is a multicatalytic intracellular protease that catalyzes the degradation of both normal (native) and abnormal (misfolded and/or damaged) proteins.

Malondialdehyde-Acetaldehyde Adduct Formation Decreases Immunoglobulin A Transport across Airway Epithelium in Smokers Who Abuse Alcohol.

Alcohol misuse and smoking are risk factors for pneumonia, yet the impact of combined cigarette smoke and alcohol on pneumonia remains understudied. Smokers who misuse alcohol form lung malondialdehyde-acetaldehyde (MAA) protein adducts and have decreased levels of anti-MAA secretory IgA (sIgA). Transforming growth factor-β (TGF-β) down-regulates polymeric Ig receptor (pIgR) on mucosal epithelium, resulting in decreased sIgA transcytosis to the mucosa.

What's eating you? cat flea (Ctenocephalides felis) revisited.

Cat fleas (Ctenocephalides felis) often leave cats and dogs to bite humans, causing pruritic lesions of the lower extremities. Once flea bites are confirmed, various efforts can be made to eradicate these pests from the home or pets. Cat fleas also play a role in transmission of vector-borne diseases, especially endemic typhus.

Aquatic antagonists: stingray injury update.

Stingrays cause more sting-related injuries than any other fish. Their venom and mechanism of injury lead to painful, poor-healing wounds that often become infected. Stingray injuries are further complicated by retained barbs and foreign bodies, which also may lead to considerable morbidity.