Publications by authors named "Gagandeep Singh"

Objective: The antifungal audit aimed to evaluate antifungal usage in a tertiary care center. It focused on patient profiles, the appropriateness of antifungal use, associated adverse drug reactions, reasons for suboptimal usage, and the economic burden caused by prolonged non-optimal antifungal use.

Method: ology: Conducted at All India Institute of Medical Sciences, New Delhi, India from January 2019 to December 2020, the study evaluated systemic antifungal use in 100 hospitalized adults with invasive fungal infections.

View Article and Find Full Text PDF

It is very rare to see fungal arthritis and pyomyositis in immunocompetent patients. Here, we report a case of Scedosporium infection in an immunocompetent patient with interesting 18F-FDG PET/CT and 68Ga-NOTA UBI PET/CT findings.

View Article and Find Full Text PDF

The rapid development of coronavirus disease 2019 (COVID-19) vaccines has helped mitigate the initial impact of the pandemic. However, in order to reduce transmission rates and protect more vulnerable and immunocompromised individuals unable to mount an effective immune response, development of a next-generation of mucosal vaccines is necessary. Here, we developed an intranasal Newcastle disease virus (NDV)-based vaccine expressing the spike of the XBB.

View Article and Find Full Text PDF

Antigenically distinct SARS-CoV-2 variants increase the reinfection risk for vaccinated and previously exposed population due to antibody neutralization escape. COVID-19 severity depends on many variables, including host immune responses, which differ depending on genetic predisposition. To address this, we perform immune profiling of female mice with different genetic backgrounds -transgenic K18-hACE2 and wild-type 129S1- infected with the severe B.

View Article and Find Full Text PDF

COX-2 and 5-LOX are major enzymes implicated in inflammatory processes and have a crucial role in the pathogenesis of inflammatory disorders and malignancies. Designing antagonists that may concurrently interact with several receptors is a viable technique; thus, blocking these two targets with a single chemical compound might provide an efficient therapeutic approach. In-silico approaches have been employed to find polypharmacological inhibitors, especially for drug repurposing and multitarget drug design.

View Article and Find Full Text PDF

Basecalling is an essential step in nanopore sequencing analysis where the raw signals of nanopore sequencers are converted into nucleotide sequences, that is, reads. State-of-the-art basecallers use complex deep learning models to achieve high basecalling accuracy. This makes basecalling computationally inefficient and memory-hungry, bottlenecking the entire genome analysis pipeline.

View Article and Find Full Text PDF

Cereals, grains, and feedstuffs are prone to contamination by fungi during various stages from growth to storage. These fungi may produce harmful mycotoxins impacting food quality and safety. Thus, the development of quick and reliable methods for on-site application is crucial for ensuring food safety and quality monitoring.

View Article and Find Full Text PDF
Article Synopsis
  • Recent research indicates that both neutralizing and non-neutralizing antibodies can help protect against severe COVID-19, even when non-neutralizing antibodies don’t directly neutralize the virus.* -
  • Non-neutralizing antibodies may recruit immune cells to help clear infected cells and often bind to virus parts that are conserved across different variants.* -
  • The study analyzed 42 human monoclonal antibodies from vaccinated individuals, finding that some non-neutralizing antibodies can provide protection in animal models, highlighting their potential role in immunity.*
View Article and Find Full Text PDF

Bacterial resistance to antibiotics and the number of patients infected by multi-drug-resistant bacteria have increased significantly over the past decade. This study follows a computational approach to identify potential antibacterial compounds from wild mushrooms. Twenty-six known compounds produced by wild mushrooms were docked to assess their affinity with drug targets of antibiotics such as penicillin-binding protein-1a (PBP1a), DNA gyrase, and isoleucyl-tRNA synthetase (ILERS).

View Article and Find Full Text PDF

A fifteen-year-old boy was brought to emergency department with complaints of altered sensorium, aphasia and right sided hemiparesis following severe dengue one month back. On physical examination, tone was flaccid and power was diminished in right upper and lower limbs. Reflexes were diminished in all four limbs.

View Article and Find Full Text PDF

The incidence of status epilepticus is possibly increased in low- and low-middle income countries but paradoxically, there are more challenges in the management of the condition in these countries. These challenges include the lack of recognition of status epilepticus in the community, impenetrable access to treatment and non-availability of medications to treat status epilepticus. We propose that status epilepticus be an index condition and an entry-point for improving emergency care for neurological disorders in low- and low-middle income countries.

View Article and Find Full Text PDF

Background: The oncologic benefit of liver resection for colorectal liver metastases (CRLM) in the setting of concurrent extrahepatic disease (EHD) is controversial. We performed a population-based, cross-sectional study to determine the practice patterns and overall survival (OS) of patients with CRLM + EHD who underwent liver resection.

Methods: Patients with CRLM + EHD were identified using the California Cancer Registry from 2000 to 2019.

View Article and Find Full Text PDF
Article Synopsis
  • Scientists are focused on creating new medicines to fight the virus that causes COVID-19, called SARS-CoV-2.
  • They tested a special treatment called 5'END-2, which is good at stopping the virus from growing in lab cells and mice.
  • The results showed that using 5'END-2 in mice helped reduce the virus in their lungs, suggesting it might be a promising way to treat COVID-19.
View Article and Find Full Text PDF

Gliomas and Glioblastomas represent a significant portion of central nervous system (CNS) tumors associated with high mortality rates and variable prognosis. In 2021, the World Health Organization (WHO) updated its Glioma classification criteria, most notably incorporating molecular markers including CDKN2A/B homozygous deletion, TERT promoter mutation, EGFR amplification, + 7/-10 chromosome copy number changes, and others into the grading and classification of adult and pediatric Gliomas. The inclusion of these markers and the corresponding introduction of new Glioma subtypes has allowed for more specific tailoring of clinical interventions and has inspired a new wave of Radiogenomic studies seeking to leverage medical imaging information to explore the diagnostic and prognostic implications of these new biomarkers.

View Article and Find Full Text PDF
Article Synopsis
  • Neurocysticercosis is a big cause of seizures and epilepsy in some areas of the world that struggle to control the infection.
  • Many of the seizures caused by this infection are called "acute symptomatic seizures," but this name isn't really right because the condition isn't just temporary.
  • The text suggests that seizures should be classified based on the stage of the infection and also points out that there are other health issues related to neurocysticercosis that need to be recognized.
View Article and Find Full Text PDF

The unregulated use of pesticides, industrial discharge of heavy metals, waste, and agricultural runoff may contaminate surface water and groundwater, consequently threatening ecosystems and human health. Thus, the sensitive detection and degradation of pesticides are essential for safety. In this context, herein, we have developed benzimidazolium-based fluorescent surfactant assemblies and , which exhibit aggregation-induced emission enhancement in an aqueous medium.

View Article and Find Full Text PDF
Article Synopsis
  • - The study analyzed patient experiences with remote telemonitoring during GI oncologic surgery, highlighting improved communication and access to healthcare providers for those in the intervention group who received extra nursing support.
  • - Out of 114 patients, 100 participated in exit interviews, revealing that 94% of those in the intervention group found the data reporting easier compared to 69% in standard care, with key themes of positivity towards recovery and timely healthcare responses.
  • - Overall, patients reported high satisfaction with the telemonitoring program, suggesting that it could be beneficial for future patient care and recovery strategies.
View Article and Find Full Text PDF
Article Synopsis
  • A 52-year-old male developed severe weakness and was hospitalized due to hypokalemia and rhabdomyolysis after increasing his chlorthalidone dosage from 25 mg to 50 mg daily.
  • Extensive testing eliminated other potential causes of his hypokalemia, indicating it was likely due to the medication.
  • The patient's condition improved significantly with potassium supplementation and stopping the chlorthalidone, highlighting the need for awareness about serious side effects of diuretics even with minor dose adjustments.
View Article and Find Full Text PDF

: Although survival outcomes for neuroendocrine liver metastases (NETLM) are improved with liver-direct therapies (LDT), including hepatic debulking and nonsurgical trans-arterial embolization, the benefit is less established in the setting of concurrent extrahepatic disease (EHD). We performed a population-based study to characterize the rates of LDT being performed for NETLM with EHD patients and whether LDT is associated with survival outcomes. : Patients with NETLM and EHD were identified using the California Cancer Registry database merged with data from the California Office of Statewide Health Planning and Development between 2000 and 2012.

View Article and Find Full Text PDF