Publications by authors named "Gaetano Licata"
Background: The incidence of skin cancer in patients with systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) has only been investigated with retrospective studies enrolling a low number of patients. The aims of our study were to assess the incidence of skin cancer in two large cohorts of patients, one with SLE and the other with SSc and investigating possible risk factors.
Methods: Ninety SLE, 53 SSc patients and 392 control subjects were enrolled.
Article Synopsis
- Nonmelanoma skin cancers (NMSC), specifically basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), usually occur on sun-exposed skin but can also appear in covered areas like the genital region, where they may exhibit variable pigmentation.
- Accurate diagnosis is crucial due to the risk of mucosal melanoma, and this review discusses the diagnosis and management of pigmented NMSC (pNMSC) in the genital area, highlighting the importance of dermoscopy and reflectance confocal microscopy in assessment.
- Pigmented variants of BCC and SCC are rare, with specific dermoscopic features noted for diagnosis, and it is essential to differentiate pNMSC from benign lesions and melanoma to ensure appropriate treatment.
Comparative effectiveness of tildrakizumab 200 mg versus tildrakizumab 100 mg in psoriatic patients with high disease burden or above 90 kg of body weight: a 16-week multicenter retrospective study - IL PSO (Italian landscape psoriasis).
J Dermatolog Treat
December 2024
Purpose: Tildrakizumab is a selective inhibitor of IL-23 approved for the treatment of moderate-to-severe plaque psoriasis in two dosages. We conducted a 16-week multicenter retrospective study to compare the effectiveness and safety of tildrakizumab 200 mg versus tildrakizumab 100 mg in patients with a high disease burden or high body weight.
Materials And Methods: Our retrospective study included 134 patients treated with tildrakizumab 200 mg and 364 patients treated with tildrakizumab 100 mg from 28 Italian Dermatology Units affected by moderate-to-severe plaque psoriasis.
Introduction: Seborrheic keratoses (SK), are very common benign skin lesions, which may increase in number and size with age.
Objectives: The aim of the study was to assess any differences seen in seborrheic keratoses in relation to different skin types (ST) and lesion location.
Methods: This was a retrospective observational study of 10-months period, based on dermoscopic images of seborrheic keratoses and patient history recorded in database.
Cutaneous syncytial myoepithelioma (CSM) is a rare type of cutaneous neoplasm that typically presents as a solitary and well-circumscribed nodule on the skin. It predominantly occurs on the upper and lower extremities of adult patients. Immunohistochemically, CSM is characterized by the co-expression of smooth muscle and epithelial markers.
View Article and Find Full Text PDFBackground: Little information is available from real-life studies evaluating the efficacy of apremilast in moderate-to-severe psoriasis.
Methods: In this real-life study, we retrospectively examined a database of 231 patients with moderate-to-severe psoriasis treated with apremilast (30 mg twice/day) and followed up for 52 weeks. Disease severity and treatment response were assessed by the Psoriasis Area and Severity Index (PASI) at baseline and after 16, 24, and 52 weeks.
Background: Extra facial lentigo maligna (EF-LM) arises outside the head and neck area. EF-LM presents the classic histological features of lentigo maligna. The dermoscopic aspects of EF-LM have been poorly studied.
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- Several inflammatory scalp conditions often require long-term treatment, leading to the exploration of alternative therapies.
- A case series involving 22 patients with conditions like lichen planus pilaris and discoid lupus used a topical solution of tacrolimus (0.1%) applied in a gradual regimen.
- Results showed that after two months, most patients experienced significant improvement, indicating tacrolimus could be a potent and safe option for maintaining treatment for these scalp conditions.
Surgical margin mapping for lentigo maligna and lentigo maligna melanoma: traditional technique (visual inspection with dermoscopy) versus combined paper tape and reflectance confocal microscopy technique.
Int J Dermatol
June 2023
Background: The detection of subclinical margin in lentigo maligna/lentigo maligna melanoma (LM/LMM) can be challenging for the dermatologist. Reflectance confocal microscopy (RCM) enables to observe in vivo atypical melanocytes beyond the clinical margins. The aim of this study is to establish which of these methods (clinical examination and dermoscopy versus "Paper tape - RCM") is more precise to define the lesion margin and to reduce the number of re-intervention and overtreatments in cosmetically sensitive areas.
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- Down syndrome (DS) is the most prevalent chromosomal disorder, with patients often experiencing skin issues like psoriasis and atopic dermatitis, which can be treated with biological drugs.
- A study examined the effectiveness of these drugs in 7 patients (4 adults and 3 minors), revealing significant improvement in psoriasis symptoms over 24 weeks, with reductions in severity and impact on quality of life.
- The findings suggest that while no official treatment guidelines for psoriasis in DS patients exist, anti-TNFα drugs like adalimumab and newer anti-interleukin medications show promise with good tolerability and effectiveness.