Misfolded alpha-synuclein in amyotrophic lateral sclerosis: Implications for diagnosis and treatment.

Background: Alpha-synuclein (α-Syn) oligomers and fibrils have been shown to augment the aggregation of TAR DNA-binding Protein 43 (TDP-43) monomers in vitro, supporting the idea that TDP-43 proteinopathies such as ALS may be modulated by the presence of toxic forms of α-Syn. Recently, parkinsonian features were reported in a study of European patients and Lewy bodies have been demonstrated pathologically in a similar series of patients. Based on these and other considerations, we sought to determine whether seed-competent α-Syn can be identified in spinal fluid of patients with ALS including familial, sporadic, and Guamanian forms of the disease.

Deep intracochlear injection of triamcinolone-acetonide with an inner ear catheter in patients with residual hearing.

Introduction: In a previous study, an inner ear catheter was used to deliver low- and high-dose steroids into the cochlea prior to cochlear implant electrode insertion. With this approach, more apical regions of the cochlea could be reached and a reduction of electrode impedances in the short term was achieved in cochlear implant recipients. Whether intracochlear application of drugs via the catheter is a safe method also for patients with residual hearing has not been investigated hitherto.

Automatic threat processing shows evidence of exclusivity.

De Neys argues against assigning exclusive capacities to automatic versus controlled processes. The dual implicit process model provides a theoretical rationale for the exclusivity of automatic threat processing, and corresponding data provide empirical evidence of such exclusivity. De Neys's dismissal of exclusivity is premature and based on a limited sampling of psychological research.

A multi-lab test of the facial feedback hypothesis by the Many Smiles Collaboration.

Following theories of emotional embodiment, the facial feedback hypothesis suggests that individuals' subjective experiences of emotion are influenced by their facial expressions. However, evidence for this hypothesis has been mixed. We thus formed a global adversarial collaboration and carried out a preregistered, multicentre study designed to specify and test the conditions that should most reliably produce facial feedback effects.

Correction to: On the Automatic Nature of Threat: Physiological and Evaluative Reactions to Survival-Threats Outside Conscious Perception.

[This corrects the article DOI: 10.1007/s42761-021-00090-6.].

On the Automatic Nature of Threat: Physiological and Evaluative Reactions to Survival-Threats Outside Conscious Perception.

Unlabelled: A neural architecture that preferentially processes immediate survival threats relative to other negatively and positively valenced stimuli presumably evolved to facilitate survival. The empirical literature on threat superiority, however, has suffered two problems: methodologically distinguishing threatening stimuli from negative stimuli and differentiating whether responses are sped and strengthened by threat superiority or delayed and diminished by conscious processing of nonthreatening stimuli. We addressed both problems in three within-subject studies that compared responses to empirically validated sets of threating, negative, positive, and neutral stimuli, and isolated threat superiority from the opposing effect of conscious attention by presenting stimuli outside conscious perception.

Female advantage in threat avoidance manifests in threat reaction but not threat detection.

Threat avoidance involves both detection of a threatening stimulus and reaction to it. We demonstrate with empirically validated stimuli (that are threatening, nonthreatening-negative, neutral, or positive) that threat detection is more pronounced among males, whereas threat reactivity is more pronounced among females. Why women are less efficient detectors of threat challenges Benenson et al.

Fact or artifact? Demand characteristics and participants' beliefs can moderate, but do not fully account for, the effects of facial feedback on emotional experience.

The facial feedback hypothesis suggests that an individual's facial expressions can influence their emotional experience (e.g., that smiling can make one feel happier).

Danger or dislike: Distinguishing threat from negative valence as sources of automatic anti-Black bias.

The Dual Implicit Process Model (March et al., 2018b) distinguishes the implicit processing of physical threat (i.e.

A method for estimating the time of initiating correct categorization in mouse-tracking.

Mouse-tracking facilitates exploration of the mental processes underlying decision-making. As the cognitive system works to settle on a decision, response competition manifests in the motor movements of the hand, bringing the mouse relatively closer to one alternative versus the other. Many metrics provide insight into decision-making processes by indexing the shape or complexity of the mouse trajectory.

Dose-Dependent Transient Decrease of Impedances by Deep Intracochlear Injection of Triamcinolone With a Cochlear Catheter Prior to Cochlear Implantation-1 Year Data.

Administration of low-dose steroids via a catheter inserted into the cochlea to apply pharmaceuticals to more apical regions was previously shown not to be sufficient for long-term reduction of electrode impedances. The aim of the present study was to investigate the effect of intra-cochlear high-dose triamcinolone application on impedances in cochlear implant recipients. Patients received low-dose (4 mg/ml; = 5) or high-dose (20 mg/ml; = 5) triamcinolone via a cochlear catheter just prior to the insertion of a Med-El Flex28 electrode.

Patients' recovery after severe TBI is associated with their close relatives' interpersonal functioning: a 12-months prospective cohort study.

The aim of this study was to investigate the association between relatives' interpersonal functioning and patients' recovery after severe traumatic brain injury (TBI) across one year in Switzerland. : This prospective, multi-center cohort study is comprised of 188 adult patients with severe TBI (Abbreviated Head Injury Score > 3) and their relatives. Patients and relatives were assessed 3, 6, and 12 months post-injury.

"Our Country Needs a Strong Leader Right Now": Economic Inequality Enhances the Wish for a Strong Leader.

Societal inequality has been found to harm the mental and physical health of its members and undermine overall social cohesion. Here, we tested the hypothesis that economic inequality is associated with a wish for a strong leader in a study involving 28 countries from five continents (Study 1, = 6,112), a study involving an Australian community sample (Study 2, = 515), and two experiments (Study 3a, = 96; Study 3b, = 296). We found correlational (Studies 1 and 2) and experimental (Studies 3a and 3b) evidence for our prediction that higher inequality enhances the wish for a strong leader.

Intracochlear administration of steroids with a catheter during human cochlear implantation: a safety and feasibility study.

Suppression of foreign body reaction, improvement of electrode-nerve interaction, and preservation of residual hearing are essential research topics in cochlear implantation. Intracochlear pharmaco- or cell-based therapies can open new horizons in this field. Local drug delivery strategies are desirable as higher local concentrations of agents can be realized and side effects can be minimized compared to systemic administrations.

Cancer Diagnosis: A Trauma for Patients and Doctors Alike.

The quality of communication between oncologists and patients can have a direct effect on each individual's coping mechanisms for dealing with stress, especially when dealing with the stress of a cancer diagnosis. This report applies the findings of trauma research to this aspect of oncological care.

Motivational (con)fusion: Identity fusion does not quell personal self-interest.

We question whether altruistic motivation links identity fusion and extreme self-sacrifice. We review two lines of research suggesting that the underlying motivation is plausibly egoistic.

In Harm's Way: On Preferential Response to Threatening Stimuli.

Given the evolutionary significance of survival, the mind might be particularly sensitive (in terms of strength and speed of reaction) to stimuli that pose an immediate threat to physical harm. To rectify limitations in past research, we pilot-tested stimuli to obtain images that are threatening, nonthreatening-negative, positive, or neutral. Three studies revealed that participants (a) were faster to detect a threatening than nonthreatening-negative image when each was embedded among positive or neutral images, (b) oriented their initial gaze more frequently toward threatening than nonthreatening-negative, positive, or neutral images, and (c) evidenced larger startle-eyeblinks to threatening than to nonthreatening-negative, positive, or neutral images.

Does self-enhancement facilitate task performance?

Self-enhancement is a pervasive motivation that manifests broadly to promote and protect the positivity of the self. Research suggests that self-enhancement is associated with improved task performance. Untested, however, is whether that association is causal.

Strangers With Benefits: Attraction to Outgroup Men Increases as Fertility Increases Across the Menstrual Cycle.

Research typically reveals that outgroups are regarded with disinterest at best and hatred and enmity at worst. Working from an evolutionary framework, we identify a unique pattern of outgroup attraction. The small-group lifestyle of pre-human ancestors plausibly limited access to genetically diverse mates.

Revisiting the Measurement of Anomie.

Sociologists coined the term "anomie" to describe societies that are characterized by disintegration and deregulation. Extending beyond conceptualizations of anomie that conflate the measurements of anomie as 'a state of society' and as a 'state of mind', we disentangle these conceptualizations and develop an analysis and measure of this phenomenon focusing on anomie as a perception of the 'state of society'. We propose that anomie encompasses two dimensions: a perceived breakdown in social fabric (i.

Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases.

Mutations of the human valosin-containing protein gene cause autosomal-dominant inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia. We identified strumpellin as a novel valosin-containing protein binding partner. Strumpellin mutations have been shown to cause hereditary spastic paraplegia.

It's not WEIRD, it's WRONG: when researchers overlook uNderlying genotypes, they will not detect universal processes.

We dispute Henrich et al.'s analysis of cultural differences at the level of a narrow behavioral-expression for assessing a universalist argument. When Researchers Overlook uNderlying Genotypes (WRONG), they fail to detect universal processes that generate observed differences in expression.

Mechanisms of moral disengagement and their differential use by right-wing authoritarianism and social dominance orientation in support of war.

Right-wing authoritarianism (RWA) and social dominance orientation (SDO) are associated with the approval of war as a political intervention [McFarland, 2005]. We examined whether the effects of RWA and SDO on war support are mediated by moral-disengagement mechanisms [i.e.

The Advanced Bionics High Resolution Mode: stimulation rates up to 5000 pps.

Conclusion: The technology of stimulation rates between 1500 and 5000 pulses per second per channel (pps/ch) brings a benefit for all users. However, the fastest possible rate does not necessarily lead to best hearing performance in each individual subject. Individual optimization of stimulation rate is recommended.