Computational Analysis of the Mutual Constraints between Single-Cell Growth and Division Control Models.

Three models of division control are proposed to achieve cell size homeostasis: sizer, timer, and adder. However, few published studies of division control take into account the dynamics of single-cell growth and most assume that single-cell growth is exponential. Here, computational simulations considering exponential, linear, and bilinear growth models are performed.

A biphasic growth model for cell pole elongation in mycobacteria.

Mycobacteria grow by inserting new cell wall material in discrete zones at the cell poles. This pattern implies that polar growth zones must be assembled de novo at each division, but the mechanisms that control the initiation of new pole growth are unknown. Here, we combine time-lapse optical and atomic force microscopy to measure single-cell pole growth in mycobacteria with nanometer-scale precision.