Publications by authors named "Gaelle Labrunie"
Cell-assembled extracellular matrix (CAM) has been used to produce vascular grafts. While these completely biological vascular grafts performed well in clinical trials, the in vivo remodeling and inflammatory response of this truly "bio" material has not yet been investigated. In this study, human CAM yarns were implanted subcutaneously in nude rats to investigate the innate immune response to this matrix.
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- In tissue engineering, the extracellular matrix produced by cells serves as a scaffold that offers structural support, and researchers have developed a method to mass-produce Cell-Assembled extracellular Matrix (CAM) using human fibroblasts.
- This article introduces CAM yarns that exhibit diverse physical and mechanical properties, usable from simple sutures to creating fully biological tissue-engineered vascular grafts (TEVGs) with high mechanical strength for implantation.
- The innovative technique combines biological materials with textile assembly methods to create versatile medical textiles, which meet or exceed clinical standards for strength and integration into the human body.
G-quadruplex ligands exert their antiproliferative effects through telomere-dependent and telomere-independent mechanisms, but the inter-relationships among autophagy, cell growth arrest and cell death induced by these ligands remain largely unexplored. Here, we demonstrate that the G-quadruplex ligand 20A causes growth arrest of cancer cells in culture and in a HeLa cell xenografted mouse model. This response is associated with the induction of senescence and apoptosis.
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- The study investigated the Cell-Assembled extracellular Matrix (CAM) created from human skin fibroblasts, confirming its effectiveness as a biological vascular graft previously tested in clinical settings.
- Researchers analyzed the composition and organization of CAM, identifying over 50 proteins and highlighting its dense collagen network and tissue-like properties.
- The findings showed that a devitalization process (dehydration) used for storage did not negatively impact the mechanical strength or structural organization of CAM, making it suitable for off-the-shelf use without adverse effects on its functionality.
A series of novel 2,4,6-triarylpyridines have been synthesized and their interactions with intramolecular G-quadruplexes have been measured by Förster Resonance Energy Transfer (FRET) melting and Fluorescent Intercalator Displacement (FID) assays. A few of these compounds exhibit stabilization of G4-DNA that is comparable to other benchmark G4-DNA ligands with fair to excellent G4-DNA vs. duplex selectivity and significant cytotoxicity towards HeLa cells.
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