Publications by authors named "Gaelle Giacometti"
Article Synopsis
- Group B Streptococcus (GBS) is a major cause of severe infections in newborns, and preventing these infections involves giving antibiotics to GBS-colonized pregnant women during labor.
- The study evaluated the effectiveness of two rapid tests, Ampliflash® GBS and PlusLife® GBS, for detecting GBS in vaginal samples, comparing them with traditional culture methods.
- Results showed that both tests were highly sensitive and specific, providing quick results within 10 to 35 minutes, indicating they could be more efficient in preventing GBS-related neonatal diseases than current screening methods, but further research is necessary.
Article Synopsis
- Graft-versus-host disease (GVHD) is a serious complication in unrelated donor hematopoietic cell transplantation (HCT), impacted by mismatches in the MICA gene that plays a role in immune responses.
- A study of 922 HCT pairs found that mismatches in MICA increased the risk of severe acute GVHD and chronic GVHD, along with higher nonrelapse mortality rates, while also showing a lower risk for cancer relapse.
- Selecting donors that are MICA-matched can improve patient outcomes significantly, as the close genetic link between MICA and HLA-B aids in identifying suitable donors easily.
Article Synopsis
- * The study highlights that for effective T cell stimulation by a specific lipid (PIM(6)), the lipid needs prior digestion by an enzyme, and CD1e is crucial for this process, acting as a lipid transfer protein.
- * CD1e not only facilitates the digestion of PIM(6) based on how they are modified but also ensures the proper transfer and presentation of these lipids to T cells, improving our understanding of immune responses.
Article Synopsis
- CD1e is a unique human protein located in dendritic cells that helps process glycolipid antigens for T cell recognition, but its exact role is still unclear.
- Researchers solved the crystal structure of CD1e, revealing a simpler groove shape compared to other CD1 proteins, potentially allowing for quicker lipid interactions.
- The findings suggest CD1e may play a key role in lipid exchange with CD1b, possibly enhancing the variety of lipid antigens presented by dendritic cells.
The plasma membrane proteins CD1a, CD1b and CD1c are expressed by human dendritic cells, the professional antigen-presenting cells of the immune system, and present lipid antigens to T lymphocytes. CD1e belongs to the same family of molecules, but accumulates as a membrane-associated form in the Golgi compartments of immature dendritic cells and as a soluble cleaved form in the lysosomes of mature dendritic cells. In lysosomes, the N-terminal propeptide of CD1e is also cleaved, but the functional consequences of this step are unknown.
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