Publications by authors named "Gaelle Duvallet"
Oxaliplatin was nearly twice as hematotoxic, with optimal circadian timing differing by 6 h, in women as compared to men with colorectal cancers. Hence, we investigated sex- and timing-related determinants of oxaliplatin hematopoietic toxicities in mice. Body-weight loss (BWL), blood cell counts, bone marrow cellularity (BMC) and seven flow-cytometry-monitored hematopoietic progenitor populations were evaluated 72 h after oxaliplatin chronotherapy administration (5 mg/kg).
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- Breast cancer is the most prevalent cancer globally and a leading cause of cancer deaths among women, with studies linking night-shift work and circadian disruption to increased cancer risk.
- The research uses a mouse model to explore how chronic jetlag affects mammary tumor development, revealing that circadian disruption accelerates cancer spread and alters the tumor environment.
- The findings suggest that using a CXCR2 inhibitor may help counteract the negative effects of chronic circadian disruption on breast cancer progression.