Publications by authors named "Gaelen Adam"
Context: Treatments for obsessive-compulsive disorder (OCD) in children and adolescents.
Objective: Evaluate the comparative efficacy of behavioral and pharmacologic treatments.
Data Sources: Six databases and ClinicalTrials.
Context: Children and adolescents with suspected obsessive-compulsive disorder (OCD).
Objective: To estimate the comparative performance of brief diagnostic assessment tools.
Data Sources: PubMed, the Cochrane Register of Clinical Trials, the Cochrane Database of Systematic Reviews, Embase, CINAHL, PsycINFO, and ERIC, and for unpublished studies with reported results in ClinicalTrials.
Objectives: Development of search queries for systematic reviews (SRs) is time-consuming. In this work, we capitalize on recent advances in large language models (LLMs) and a relatively large dataset of natural language descriptions of reviews and corresponding Boolean searches to generate Boolean search queries from SR titles and key questions.
Materials And Methods: We curated a training dataset of 10 346 SR search queries registered in PROSPERO.
Article Synopsis
- In 2021, the KDIGO published updated guidelines for managing glomerular diseases, focusing on the latest findings in nephrology.
- The approval of avacopan in late 2021 for treating ANCA-associated vasculitis prompted significant updates to the guidelines.
- The new evidence supports using lower-dose glucocorticoids, or even eliminating them, during treatment for better patient outcomes.
Study Objectives: We performed a systematic review of long-term health outcomes of continuous positive airway pressure (CPAP) use in adults with obstructive sleep apnea.
Methods: We updated prior systematic reviews with searches in multiple databases through January 3, 2023. We included randomized controlled trials (RCTs) and adjusted nonrandomized comparative studies that reported prespecified long-term (mostly > 1 year) health outcomes.
Article Synopsis
- * Advances in drug development have surged due to new genetic and molecular insights into these diseases, prompting KDIGO to commit to regular updates of their guidelines.
- * The first update post-2021 guideline includes new recommendations based on two newly approved drugs for lupus nephritis, summarized for quick reference.
Objective: A decline in musculoskeletal health during pregnancy is an underappreciated adverse outcome of pregnancy that can have immediate and long-term health consequences. High physical job demands are known risk factors for nontraumatic musculoskeletal disorders in the general working population. Evidence from meta-analyses suggest that occupational lifting and prolonged standing during pregnancy may increase risk of adverse pregnancy outcomes.
View Article and Find Full Text PDFPrevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2022 Clinical Practice Guideline.
Ann Intern Med
December 2023
Description: The Kidney Disease: Improving Global Outcomes (KDIGO) 2022 clinical practice guideline on prevention, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease (CKD) is an update of the 2018 guideline from KDIGO.
Methods: The KDIGO Work Group (WG) updated the guideline, which included reviewing and grading new evidence that was identified and summarized. As in the previous guideline, the WG used the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to appraise evidence and rate the strength of recommendations and used expert judgment to develop recommendations.
Study Objectives: We explored the variability of sleep apnea indices and definitions of obstructive sleep apnea in clinical studies of continuous positive airway pressure.
Methods: In a systematic review of the long-term clinical effects of continuous positive airway pressure, we noted variability across studies in how sleep apnea was defined. We, thus, sought to quantify the heterogeneity.
Assets and depression in U.S. adults during the COVID-19 pandemic: a systematic review.
Soc Psychiatry Psychiatr Epidemiol
April 2024
Purpose: Mental health is shaped by social and economic contexts, which were altered during the COVID-19 pandemic. No study has systematically reviewed the literature on the relation between different assets and depression during the COVID-19 pandemic.
Methods: We conducted a systematic review of the literature on financial (e.
Objective: To systematically review the effects of postpartum health care-delivery strategies on health care utilization and maternal outcomes.
Data Sources: We searched Medline, EMBASE, CENTRAL, CINAHL, and ClinicalTrials.gov for studies in the United States or Canada from inception to November 16, 2022.
Objective: To assess the effectiveness of postpartum home blood pressure (BP) monitoring compared with clinic-based follow-up and the comparative effectiveness of alternative home BP-monitoring regimens.
Data Sources: Search of Medline, Cochrane, EMBASE, CINAHL, and ClinicalTrials.gov from inception to December 1, 2022, searching for home BP monitoring in postpartum individuals.
Objective: To compare benefits and harms of televisits and in-person visits in people receiving routine antenatal care.
Data Sources: A search was conducted of PubMed, Cochrane databases, EMBASE, CINAHL, and ClinicalTrials.gov through February 12, 2022, for antenatal (prenatal) care, pregnancy, obstetrics, telemedicine, remote care, smartphones, telemonitoring, and related terms, as well as primary study designs.
Objective: To assess differences in maternal and child outcomes in studies comparing reduced routine antenatal visit schedules with traditional schedules.
Data Sources: A search was conducted of PubMed, Cochrane databases, EMBASE, CINAHL, and ClinicalTrials.gov through February 12, 2022, searching for antenatal (prenatal) care, pregnancy, obstetrics, telemedicine, remote care, smartphones, telemonitoring, and related terms, as well as primary study designs.
Importance: Approximately half of postpartum individuals in the US do not receive any routine postpartum health care. Currently, federal Medicaid coverage for pregnant individuals lapses after the last day of the month in which the 60th postpartum day occurs, which limits longer-term postpartum care.
Objective: To assess whether health insurance coverage extension or improvements in access to health care are associated with postpartum health care utilization and maternal outcomes within 1 year post partum.
While the association between assets and depression has been established, less is known about the link between financial strain and depression. Given rising financial strain and economic inequity due to the COVID-19 pandemic, understanding the role that financial strain plays in shaping population depression in the United States is particularly salient. We conducted a scoping review of the peer-reviewed literature on financial strain and depression published from inception through January 19, 2023, in Embase, Medline via PubMed, and PsycINFO, PsycArticles, SocINDEX, and EconLit via Ebsco.
View Article and Find Full Text PDFRationale & Objective: Direct-acting antiviral (DAA) treatment of hepatitis C virus (HCV) infection in patients with chronic kidney disease (CKD) has made transplantation of kidneys from HCV-infected donors to uninfected recipients (D+/R-) feasible. To facilitate an update to the 2018 KDIGO guideline for patients with CKD and HCV, we conducted a systematic review of HCV D+/R-kidney transplantation coupled with DAA treatment.
Study Design: Systematic review and meta-analysis.
Introduction: Direct-acting antivirals (DAAs) have improved treatment of hepatitis C virus (HCV) infection in patients with chronic kidney disease (CKD). To facilitate the 2022 update of the Kidney Disease: Improving Global Outcomes (KDIGO) guideline for CKD patients with HCV, we systematically reviewed DAA regimens in patients with CKD stages G4 and G5 nondialysis (G4-G5ND), CKD stage G5 on dialysis (G5D), and kidney transplant recipients (KTRs).
Methods: We conducted a systematic review by searching PubMed, Embase, Cochrane, CINAHL, and ClinicalTrials.
The COVID-19 pandemic has led to a worsening of mental health among U.S. adults.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates how caregivers make treatment decisions for children with epilepsy, highlighting the need to understand their perspectives to provide better support.
- The research involved a systematic review of qualitative studies focused on caregivers' views on medications, diets, and surgical options for epilepsy, using various academic databases.
- Key findings reveal that parents experience complex decision-making influenced by knowledge, emotions, social roles, and beliefs about treatment consequences, with a particular focus on perceptions of neurosurgery.
Objective: To systematically review patient, partner or family, and clinician perspectives, preferences, and experiences related to prenatal care visit schedules and televisits for routine prenatal care.
Data Sources: PubMed, the Cochrane databases, EMBASE, CINAHL, ClinicalTrials.gov , PsycINFO, and SocINDEX from inception through February 12, 2022.