Publications by authors named "Gael Vermeersch"

Article Synopsis
  • BCR::ABL1 negative myeloproliferative neoplasms (MPN) encompass a group of aggressive blood cancers, with primary myelofibrosis (PMF) showing the worst prognosis among them, leading to median survival rates of 16-35 months.
  • A notable complication of MPN is the progression to secondary acute myeloid leukemia (AML), which carries an even worse prognosis than de novo AML, highlighting the need for better understanding and treatment options.
  • The study focuses on the role of the cytokine CXCL8 and its receptor (CXCR1/2) in PMF pathogenesis, indicating that higher levels of CXCL8 correspond to lower survival rates, and suggests new therapeutic
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Erythrocytosis or polycythemia refers to a true or apparent increase in hemoglobin or hematocrit. When no etiology of erythrocytosis is identified, people are diagnosed with "idiopathic erythrocytosis" (IE). The identification of new contributing genes has recently improved the diagnostic workup of IE.

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Chronic neutrophilic leukemia (CNL) is a rare but potentially aggressive negative myeloproliferative neoplasm, characterized by sustained mature, neutrophilic leukocytosis. The discovery of key driver mutations in the colony-stimulating-factor-3 receptor () gene resulted in the updated World Health Organization (WHO) diagnostic criteria in 2016. A significant number of CNL cases have been associated with plasma cell dyscrasias, predominantly multiple myeloma (MM) and monoclonal gammopathy of unknown significance (MGUS).

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Background And Purpose: Enterovirus infections pose a serious threat for patients with humoral deficiencies and may be lethal, whilst the efficacy of proposed treatment options such as corticosteroids, intravenous immunoglobulins and fluoxetine remains debated.

Methods: Viral clearance was investigated in a patient with rituximab-induced B-cell depletion and chronic echovirus 13 (E13) meningoencephalitis/myofasciitis in response to intravenous immunoglobulins and fluoxetine using sequential semi-quantitative E13 viral load measurements by real-time reverse transcription polymerase chain reaction. Fluoxetine concentrations in plasma and cerebrospinal fluid were determined by liquid chromatography mass spectrometry.

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