Effect of nonsteroidal anti-inflammatory drugs in children with Bartter syndrome.

Background: Bartter syndrome (BS) is a salt-wasting tubulopathy with induced expression of cyclooxygenase-2 in the macula densa, leading to increased prostaglandin production and hyperreninemia. Nonsteroidal anti-inflammatory drugs (NSAIDs) are currently used in BS; however, there is limited information on the impact of NSAIDs at treatment initiation or the potential utility of plasma renin level to guide therapy in patients with BS.

Methods: We included 19 patients with BS treated with NSAIDs between 1994 and 2016.