Application of ulipristal acetate in female patients with uterine fibroids.

Objectives: Uterine fibroids are the most common benign tumors in women of reproductive age. Evidence suggest that ovarian steroid hormones, in particular, progesterone play a major role in promoting leiomyoma development and growth. For the last years there was an extensive research on selective progesterone receptor modulators and their use in therapy.

Cancer of the urinary bladder neovagina in a patient with Morris' syndrome.

Background: Vaginal agenesis is a rare condition, therefore the incidence of a malignant transformation in the neovagina is extremely low.

Case Report: We report on a 42-year-old patient with Morris' syndrome and urinary bladder neovagina with a history of prolonged infections of the urinary bladder and intertrigo of the perineal region. The biopsy revealed a squamous cell carcinoma arising from the neovagina.

Serum lipids concentration in women with benign and malignant ovarian tumours.

Unlabelled: Early diagnosis can improve clinical effects of ovarian carcinoma treatment. Until now, a satisfying screening method has not been found. Serum lipid and lipoprotein association with neoplasm is already established.

Efficacy and tolerability of low-dose transdermal estrogen (Oesclim) in the treatment of menopausal symptoms.

Objective: To establish the proportion of symptomatic postmenopausal women who can be satisfactorily maintained on a low HRT dose of 25 microg/day 17-beta-estradiol (Oesclim 25 transdermal patches), after 8 weeks of treatment.

Study Design And Patients: This was a multicenter open label non-comparative trial. Treatment was initiated with 25 microg/day dosage, which could be increased to 50pg/day if required after 8 weeks, according to clinical evaluation.

[The atherogenic lipid profile parameters and fibrinogen serum concentration in climacteric women under various routes of hormone replacement therapy administration].

Objectives: Influence of various routes of HTR on atherogenic lipid profile parameters and serum fibrinogen concentration was investigated.

Design: In 85 women in four groups receiving HRT transvaginally, transdermally, orally and intramuscularly, the total cholesterol, HDL-cholesterol, triglycerides, apoB, apoA, LpA and fibrinogen serum concentration was assessed before treatment and after six month.

Results: Most of tested parameters: total cholesterol, LpAI, apoB, LDL cholesterol, non HDL cholesterol, changed favorably (lowered concentration) in group using HRT orally and intramuscularly.

[The results of GnRH analog treatment of endometriosis].

Our study consisted of 146 patients with endometriosis diagnosed during laparoscopy. The age of those women varied from 19 to 43. Pathological changes were classified according to Revised American Fertility Society scale.

[The efficacy of low estrogen transdermal therapy in climacteric symptoms management].

The aim of the study was to evaluate the efficacy and tolerability of low doses estrogen transdermal system treatment in management of climacteric symptoms. On the basis of performed researches it seems to be reasonable to start hormonal replacement therapy with the very low dosage of estrogen to achieve sufficient results and avoid side effects.

Lipids in serum of patients with malignant ovarian neoplasms.

Objective: In numerous papers, different associations of serum lipids and lipoproteins with neoplastic diseases were found. The aim of our work was to find out associations between levels of 11 serum lipids, lipoproteins and ovarian cancer.

Methods: 25 healthy women and 25 patients with ovarian cancer underwent examinations.

Cancer of the larynx in Warsaw and in selected rural areas.

Incidence of the laryngeal cancer especially in males, dramatically increased in Poland. Patterns and time trend of the laryngeal cancer, based on the data from Warsaw Cancer Registry from 1963-1977 have been presented. Tobacco and alcohol consumption in Poland has been discussed considering the observed increase in laryngeal incidence.

Epidemiological evaluation of incidence of lung cancer in inhabitants of Warsaw in the period 1966--1975.

Lung cancer is most frequent in men and occupies the first place among the causes of cancer deaths. In the period 1956--1975 in Poland the incidence rate of lung cancer increased about ten times in men and seven times in women. Analysis of age-specific incidence shows a significant increase in the group age of 35--39 years in men and in 45--49 in women.