Phytochemical composition and biological activities of fruit juice.

is a plant with broad nutraceutical and therapeutic effects and used in the traditional treatment of several ailments. The objective of this work is to investigate the phytochemistry of the fruit juice of on one hand and on other hand to evaluate its antiradical and antibacterial activity. The phytochemical investigation was carried out by tube staining tests of the extract of two types of fruit juice of .

ERK1 and ERK2 activation modulates diet-induced obesity in mice.

Obesity is a worldwide problem, and dietary lipids play an important role in its pathogenesis. Recently, Erk1 knock-out (ERK1) mice have been shown to exhibit low preference for dietary fatty acids. Hence, we maintained Erk1 mice on a high-fat diet (HFD) to assess the implication of this mitogen-activated protein (MAP) kinase in obesity.

Cell mechanisms of gustatory lipids perception and modulation of the dietary fat preference.

Dietary lipids are usually responsible of several metabolic disorders. Recent compelling evidences suggest that there is a sixth taste modality, destined for the detection of oro-gustatory fats. The lipid-binding glycoprotein CD36, expressed by circumvallate papillae (CVP) of the mouse tongue, has been shown to be implicated in oro-gustatory perception of dietary lipids.

Effects of Zizyphus lotus L. (Desf.) polyphenols on Jurkat cell signaling and proliferation.

We assessed the effects of Zizyphus lotus L. (Desf.) polyphenols (ZLP) on T-cell signaling and proliferation.

STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice.

Understanding the mechanisms underlying oro-gustatory detection of dietary fat is critical for the prevention and treatment of obesity. The lipid-binding glycoprotein CD36, which is expressed by circumvallate papillae (CVP) of the mouse tongue, has been implicated in oro-gustatory perception of dietary lipids. Here, we demonstrate that stromal interaction molecule 1 (STIM1), a sensor of Ca(2+) depletion in the endoplasmic reticulum, mediates fatty acid-induced Ca(2+) signaling in the mouse tongue and fat preference.