Publications by authors named "Gadid G Guedi"
Article Synopsis
- D prostanoid receptor 1 (DP1) is crucial for reducing inflammation and protecting cartilage in osteoarthritis, but its regulation in cartilage was not well understood.
- The study focused on characterizing the human DP1 promoter and investigating how DNA methylation affects its expression in chondrocytes.
- Results showed that the transcription factor Sp1 and DNA methylation significantly influence DP1 regulation, but neither the methylation status nor expression levels of DP1 varied between normal and osteoarthritis cartilage.
Objective And Design: 15-Lipoxygenase-1 (15-LOX-1) catalyzes the biosynthesis of many anti-inflammatory and immunomodulatory lipid mediators and was reported to have protective properties in several inflammatory conditions, including osteoarthritis (OA). This study was designed to evaluate the expression of 15-LOX-1 in cartilage from normal donors and patients with OA, and to determine whether it is regulated by DNA methylation.
Methods: Cartilage samples were obtained at autopsy from normal knee joints and from OA-affected joints at the time of total knee joint replacement surgery.