The synthesis of alk-2-ynl Weinreb amides Pd/Cu-catalysed oxidative carbonylation of terminal alkynes.

Synthesis of alk-2-ynl-Weinreb amides Pd-catalyzed oxidative carbonylation of terminal alkynes and ,-dimethylhydroxylamine hydrochloride at room temperature under low CO/O pressure is reported for the first time. This protocol offers tolerance of various functional groups under mild reaction conditions. The protocol incorporates aromatic- and aliphatic-substituted alkynes through a one-step oxidative carbonylative route toward desired alkynyl Weinreb amides, which are of considerable importance as valuable synthetic building blocks.

Efficiency dynamics among onion growers in Maharashtra: a comparative analysis of drip irrigation adopters and non-adopters.

Background: Onions are economically and nutritionally important vegetable crops. Despite advances in technology and acreage, Indian onion growers face challenges in realizing their full productivity potential. This study examines the technical efficiency of onion growers, the factors influencing it, and the constraints faced by those adopting drip irrigation in the Ghod river basin of western Maharashtra.

Enhanced sunlight-driven catalysis for hydrogen generation and dye remediation using synergistic p-CoO/n-TiO nanocomposites.

In this study, p-CoO/n-TiO nanocomposites were synthesized using different ratios of cobalt and titanium precursors through a hydrothermal method. These nanocomposites demonstrated notable potential in photocatalytic applications for hydrogen production and orange-red dye degradation under sunlight. Various techniques, including XRD, Raman spectroscopy, XPS, FESEM, TEM, and BET analysis, were used to comprehensively characterize their structural, morphological, and optical properties.

Comparative stemness and differentiation of luminal and basal breast cancer stem cell type under glutamine-deprivation.

Glutamine (gln) metabolism has emerged as a cancer therapeutic target in past few years, however, the effect of gln-deprivation of bCSCs remains elusive in breast cancer. In this study, effect of glutamine on stemness and differentiation potential of bCSCs isolated from MCF-7 and MDAMB-231 were studied. We have shown that bCSCs differentiate into CD24 epithelial population under gln-deprivation and demonstrated increased expression of epithelial markers such as e-cadherin, claudin-1 and decreased expression of mesenchymal protein n-cadherin.

Synthesis of Ethylene Glycol from Syngas via Oxidative Double Carbonylation of Ethanol to Diethyl Oxalate and Its Subsequent Hydrogenation.

This work reports a novel sustainable two-step method for the synthesis of ethylene glycol (EG) using syngas. In the first step, diethyl oxalate was selectively synthesized via oxidative double carbonylation of ethanol and carbon monoxide (CO) using a ligand-free, recyclable Pd/C catalyst. In the second step, the diethyl oxalate produced underwent subsequent hydrogenation using [2-(di--butylphosphinomethyl)-6-(diethylaminomethyl)pyridine]ruthenium(II) chlorocarbonyl hydride to get EG and ethanol.

An Improved Strategy for the Synthesis of Ethylene Glycol by Oxamate-Mediated Catalytic Hydrogenation.

The present study reports an improved approach for the preparation of ethylene glycol (EG) by using carbon monoxide as C1 chemical by a two-step oxidative carbonylation and hydrogenation sequence. In the first step, oxamates are synthesized through oxidative cross double carbonylation of piperidine and ethanol by using Pd/C catalyst under phosphine ligand-free conditions and subsequently hydrogenated by Milstein's catalyst (carbonylhydrido[6-(di-t-butylphosphinomethylene)-2-(N,N-diethylaminomethyl)-1,6-dihydropyridine]ruthenium(II)). The presented stepwise oxamate-mediated coupling provides the basis for a new strategy for the synthesis of EG by selective upgrading of C1 chemicals.

Transition Metal-Catalyzed Carbonylative C-H Bond Functionalization of Arenes and C(sp(3))-H Bond of Alkanes.

In this article, we present the progress made in the area of carbonylative C-H functionalization, with special emphasis on arenes and alkanes. The importance of directing group assistance and C-H functionalization using CO surrogates is also included. The budding development in the area of transition metal-catalyzed C(sp(3))-H activation makes us feel it necessary to file a summary on the past, as well as current, contributions and a prospective outlook on the transition metal-catalyzed carbonylative transformation of C-H bonds, which is the focus of this review.

Pd(OAc)2/DABCO as an efficient and phosphine-free catalytic system for the synthesis of single and double Weinreb amides by the aminocarbonylation of aryl iodides.

This work reports a mild, stable and efficient Pd(OAc)2/DABCO catalysed protocol for the synthesis of single and double Weinreb amides. Double Weinreb amides, having 1,4-phenylene- and biphenylene-linkers - important backbones for the synthesis of biologically active symmetrical resorcylate oligomer units - were synthesized by the double carbonylation of aryl diiodides. Notably, the reaction does not require any expensive or air/moisture sensitive phosphine ligands.

Pd/C-catalyzed synthesis of oxamates by oxidative cross double carbonylation of amines and alcohols under co-catalyst, base, dehydrating agent, and ligand-free conditions.

This work reports a mild, efficient, and ligand-free Pd/C-catalyzed protocol for the oxidative cross double carbonylation of amines and alcohols. Notably, the reaction does not requires any base, co-catalyst, dehydrating agent, or ligand. Pd/C solves the problem of catalyst recovery, and the catalyst was recycled up to six times.