Publications by authors named "Gaby Zeck"

Article Synopsis
  • - This study examined the effectiveness of three different conditioning regimens (Thiotepa-Busulfan, Sequential FLAMSA-Busulfan Fludarabine, and Treosulfan-Fludarabine) prior to allogeneic stem cell transplantation (allo-SCT) in patients with Chronic myelomonocytic leukemia (CMML) from 2006 to 2022.
  • - A total of 69 CMML patients participated, with notable variations in donor type and anti-T lymphocyte Globulin use for GVHD prophylaxis across groups.
  • - Results suggested that the Thiotepa-Busulfan group experienced better 3-year overall survival (OS) rates (80%) and progression-free survival (
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Article Synopsis
  • The optimal TBI dose for patients with high-risk acute lymphoblastic leukemia (ALL) undergoing allogeneic stem cell transplantation (SCT) is still uncertain.
  • A retrospective analysis compared outcomes of patients treated with 8 Gy and 12 Gy total body irradiation (TBI) along with fludarabine and PTCy, revealing that while both doses show similar overall and leukemia-free survival, the 12 Gy dose offers better outcomes for MRD-positive patients.
  • The study suggests that the 8 Gy TBI results in lower non-relapse mortality but a higher relapse rate compared to 12 Gy, highlighting the need for further research to confirm these results with larger MRD patient groups.
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We retrospectively analyzed high-risk ALL patients in CR1 receiving total body irradiation based conditioning regimen with ATLG (n = 74) or PTCy (n = 73) for GVHD prophylaxis. The 3-year OS and LFS were similar in both groups: 65 and 60% in the ATLG group and 64 and 67% in the PTCy group (p = 0.9 and 0.

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We aimed to develop a concise objectifiable risk evaluation (CORE) tool for predicting non-relapse mortality (NRM) and overall survival (OS) after allogeneic hematopoietic stem cell transplantation (allo-HCT). A total of 1120 adult patients who had undergone allo-HCT at our center between 2013 and 2020 were divided into training, first, and second validation cohorts. Objectifiable, patient-related factors impacting NRM in univariate and multivariate analyses were: serum albumin, serum creatinine, serum C-reactive protein (CRP), heart function (LVEF), lung function (VC, FEV1), and patient age.

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Anti-T-cell lymphocyte globulin (ATLG) and posttransplant cyclophosphamide (PTCy) are now widely used strategies to prevent graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. Data comparing immune reconstitution (IR) between ATLG and PTCy is scarce. This retrospective study conducted at the University Medical Center Hamburg-Eppendorf (UKE) compares PTCy (n=123) and ATLG (n=476) after myeloablative allogeneic peripheral blood stem cell transplant.

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In this cross-sectional study, we retrospectively evaluated the files of 227 patients with myelofibrosis who underwent transplantation between 1994 and 2015 for relapse later than 5 years after allogeneic stem cell transplantation (SCT). A total of 94 patients who were alive and in remission at 5 years were identified with follow-up of at least 5 years (median, 9.15 years) after SCT.

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Introduction: Myelofibrosis (MF) is a disease of elderly with median age of 65 years at diagnosis. Allogeneic stem cell transplantation (ASCT) currently is the only potentially curative option, although associated with treatment-related morbidity and mortality. Development of reduced intensity conditioning (RIC) regimens enabled transplant to be performed successfully in older patients.

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Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment option for myelodysplastic syndromes (MDS). Little is known about the prognostic impact of mutations, for example, in TP53 specifically after allo-HSCT. We here describe the prognostic impact of mutations in a panel of 19 genes analyzed by amplicon-based next-generation-sequencing in a uniformly treated patient cohort.

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