Publications by authors named "Gaby Blaess"

Article Synopsis
  • Serum response factor (SRF) is crucial for various cellular processes like growth and movement, and it's vital for early embryonic development, specifically for forming certain structures.
  • SRF interacts with proteins CTCF and cohesin at specific genomic regions, helping to form long-range chromatin loops and manage the insulation of topologically associating domains (TADs).
  • In embryonic stem cells, SRF works with factors like SOX2 and NANOG to create three-dimensional structures that support pluripotency, indicating it has important roles in organizing chromatin at higher levels.
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SOX2 is a transcription factor involved in the regulatory network maintaining the pluripotency of embryonic stem cells in culture as well as in early embryos. In addition, SOX2 plays a pivotal role in neural stem cell formation and neurogenesis. How SOX2 can serve both processes has remained elusive.

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Article Synopsis
  • Cardiac lineage specification in mice is influenced by TGFβ and WNT signaling, with BMP being crucial for heart development across various species.* -
  • Bmp4 plays a key role in forming cardiac mesoderm in embryonic stem cells by activating Wnt3 and upregulating Nodal, leading to a cascade of signaling interactions.* -
  • The study highlights a complex interaction between Bmp4, Wnt, and Nodal pathways that ultimately suppresses neural differentiation and promotes cardiac mesoderm lineage via feedback mechanisms.*
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