[Treatment of depressed patients: current trends. Combination cognitive group therapy with cognitive adjustment for depressed inpatients].

Depressed patients represent a major part of the inpatient population. The following treatment program was developed in order to respond to this problem in a symptom- and cost-effective way. Cognitive therapy was chosen for it's learning aspect and combined with pharmacotherapy.

Acetylation of maprotiline and desmethylmaprotiline in depressive patients phenotyped with sulfamidine, debrisoquine, and mephenytoin.

A gas chromatographic/mass spectrometric method (using either electron impact or chemical ionisation with methane or ammonia) is described for the quantitative analysis of maprotiline (MP, Ludiomil), N-acetylmaprotiline (AcMP) and N-acetyldesmethylmaprotiline (AcDMP) in whole blood or plasma. In two groups (A and B) of 82 and 53 depressive patients treated clinically with MP for 10 and 21 days, respectively, plasma and whole blood MP was monitored during the treatment. In group A, all subjects were phenotyped with debrisoquine and mephenytoin, and 44 with sulfamidine.

[So-called pernicious catatonia].

After a review of the literature centered on the possible relationship of acute psychiatric symptomatology and death, more specifically in relation with acute catatonia, the writers examine all cases of schizophrenic patients admitted to the Psychiatric University Hospital of Lausanne (Hôpital de Cery) during the period from 1961 to 1981. The importance of acute catatonia is discussed and compared to other similar syndromes (the porcine stress syndrome, malignant hyperthermia, the neuroleptic "malignant" syndrome).