Publications by authors named "Gabrielle R Nelson"
Vet Anaesth Analg
August 2024
Article Synopsis
- This study investigates the effects of a transdermal buprenorphine solution on horses, comparing its pharmacokinetics and antinociceptive properties with those of an intravenous (IV) injection, hypothesizing that transdermal application would yield more stable blood levels and fewer side effects.
- Eight horses aged 6-12 were given incremental doses of the transdermal solution along with a single IV dose, with blood concentrations measured using advanced chromatography techniques, while various health indicators like heart rate and temperature were recorded to evaluate the drug’s effects.
- Results showed that transdermal buprenorphine had low systemic concentrations (only 11% bioavailability) and provided inconsistent pain
