Publications by authors named "Gabrielle Manteaux"
Nat Commun
September 2024
Article Synopsis
- Dedifferentiated and Well-differentiated liposarcoma tumors show an increase in the MDM2 oncogene, which drives tumor growth through unique metabolic functions.
- The study finds that liposarcoma cells rely on serine produced by distant muscle tissues for survival, although the source of serine is not fully understood.
- Treatment with an FDA-approved anti-interleukine-6 monoclonal antibody can hinder serine synthesis and lead to decreased tumor growth and increased cancer cell death, suggesting a potential therapy for liposarcoma patients.*
