Active surveillance for carbapenem-resistant (CRAB) carriage.

Our study's results provide promising evidence for the incorporation of a high-sensitivity carbapenem-resistant (CRAB) screening method in healthcare settings. Such an approach could prove beneficial in enhancing infection prevention and control measures, leading to improved patient outcomes and potentially alleviating the burden of CRAB in healthcare systems.

Contribution of active surveillance cultures to the control of hospital-acquired carbapenem-resistant in an endemic hospital setting.

Background: Despite the increasing rates of carbapenem-resistant (CRAB) carriage among hospitalized patients in endemic settings, the role of active surveillance cultures and cohorting is still debated. We sought to determine the long-term effect of a multifaceted infection-control intervention on the incidence of CRAB in an endemic setting.

Methods: A prospective, quasi-experimental study was performed at a 670-bed, acute-care hospital.

Identification and control of two outbreaks of unrelated New Delhi metallo-β-lactamase-producing carbapenem-resistant traced to the same endoscope defect.

We report 2 outbreaks of genetically unrelated carbapenem-resistant New Delhi metallo-β-lactamase-producing caused by contaminated duodenoscopes. Using endoscopes with disposable end caps, adherence to the manufacturer's reprocessing instructions, routine audits, and manufacturer evaluation are critical in preventing such outbreaks.

Unraveling the Diversity of Co-Colonization by CPE.

Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency event. Sporadically, patients co-colonized with distinct CPE strains and/or different carbapenemase enzymes are detected.