Synopsis of recent research by authors named "Gabrielle L Sell"
- Gabrielle L Sell's research primarily explores the molecular mechanisms underlying synapse formation and dysfunction, particularly the roles of glutamate signaling and proteins like neuroligins and neurexins in modulating synaptic connections in cortical neurons.
- The investigations into Angelman syndrome highlight the implications of UBE3A gene mutations, demonstrating that deleting a substrate related to this gene can restore impaired hippocampal function and learning capabilities in relevant mouse models.
- Sell's studies also address maternal immune activation and its effects on offspring behavior, suggesting that pre-pregnancy immunoreactivity influences susceptibility to neurodevelopmental disorders, which may provide valuable insights for therapeutic approaches.
