Publications by authors named "Gabrielle K Alves Gomes"
Synthesis and evaluation of the mutagenicity of 3-alkylpyridine marine alkaloid analogues with anticancer potential.
Maria Cristina S Barbosa Camila de Souza Barbosa Júlia T de Oliveira Natália Chermont S Moreira Natália Rezende de Miranda Martins Gabrielle K Alves Gomes
Mutat Res Genet Toxicol Environ Mutagen
January 2018
Article Synopsis
- Theonella sp is a source of biologically-active 3-alkylpyridine alkaloids (3-APAs) that have shown potential as antimalarial agents.
- Two new 3-APA analogues, designed with the thiocyanate group, were synthesized and tested against Plasmodium falciparum, revealing good antimalarial activity but high cytotoxicity towards human cells.
- Further testing on human cancer cell lines showed one compound had selective toxicity, inducing chromosomal mis-segregation and triggering apoptosis, suggesting its potential as an anticancer agent.