Publications by authors named "Gabrielle E Hardison"
Article Synopsis
- Inteins are segments that can interrupt proteins and have the ability to regulate protein function by undergoing conditional protein splicing (CPS) in response to environmental changes, such as the presence of zinc.*
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- Research utilized DnaB-intein1 (DnaBi1) to create a kanamycin resistance reporter system (KISR) to study how different insertion positions of DnaBi1 affect resistance levels, revealing that the construct showing the highest resistance was effective in probing CPS in mycobacterial conditions.*
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- Findings indicate that zinc inhibits the splicing process of DnaB, which is crucial for DNA replication in mycobacteria, by binding to the cysteine necessary for initiating splicing
