Publications by authors named "Gabrielle Colvert"
Background: Giant coronary artery aneurysms and myocardial fibrosis after Kawasaki disease may lead to devastating cardiovascular outcomes. We characterised the vascular and myocardial outcomes in five selected Kawasaki disease patients with a history of giant coronary artery aneurysms that completely regressed.
Methods: Five patients were selected who had giant coronary artery aneurysm in early childhood that regressed when studied 12-33 years after Kawasaki disease onset.
Article Synopsis
- Cardiac resynchronization therapy (CRT) can significantly help heart failure patients, but about 30% don't benefit; the study aimed to create specific maps to identify optimal lead placement for better responses.
- Researchers analyzed data from 82 subjects who underwent CRT and used advanced imaging techniques to derive left ventricle features, training a support vector machine to generate lead placement scores (LPS).
- The results showed that subjects with higher LPS scores had a much better chance of responding to CRT, with 90% response in the upper quartile, indicating the usefulness of LPS maps in predicting treatment success.
Background: The presence of left ventricular (LV) wall motion abnormalities (WMA) is an independent indicator of adverse cardiovascular events in patients with cardiovascular diseases. We develop and evaluate the ability to detect cardiac wall motion abnormalities (WMA) from dynamic volume renderings (VR) of clinical 4D computed tomography (CT) angiograms using a deep learning (DL) framework.
Methods: Three hundred forty-three ECG-gated cardiac 4DCT studies (age: 61 ± 15, 60.
Background: Estimates of regional left ventricular (LV) strains provide additional information to global function parameters such as ejection fraction (EF) and global longitudinal strain (GLS) and are more sensitive in detecting abnormal regional cardiac function. The accurate and reproducible assessment of regional cardiac function has implications in the management of various cardiac diseases such as heart failure, myocardial ischemia, and dyssynchrony.
Purpose: To develop a method that yields highly reproducible, high-resolution estimates of regional endocardial strains from 4DCT images.
Background: Regional left ventricular (LV) mechanics in mitral regurgitation (MR) patients, and local changes in function after transcatheter mitral valve implantation (TMVI) have yet to be evaluated. Herein, we introduce a method for creating high resolution maps of endocardial function from 4DCT images, leading to detailed characterization of changes in local LV function. These changes are particularly interesting when evaluating the effect of the Tendyne TMVI device in the region of the epicardial pad.
View Article and Find Full Text PDFWe present an anthropomorphically accurate left ventricular (LV) phantom derived from human computed tomography (CT) data to serve as the ground truth for the optimization and the spatial resolution quantification of a CT-derived regional strain metric (SQUEEZ) for the detection of regional wall motion abnormalities. Displacements were applied to the mesh points of a clinically derived end-diastolic LV mesh to create analytical end-systolic poses with physiologically accurate endocardial strains. Normal function and regional dysfunction of four sizes [1, 2/3, 1/2, and 1/3 American Heart Association (AHA) segments as core diameter], each exhibiting hypokinesia (70% reduction in strain) and subtle hypokinesia (40% reduction in strain), were simulated.
View Article and Find Full Text PDFWe present a method to leverage the high fidelity of computed tomography (CT) to quantify regional left ventricular function using topography variation of the endocardium as a surrogate measure of strain. 4DCT images of 10 normal and 10 abnormal subjects, acquired with standard clinical protocols, are used. The topography of the endocardium is characterized by its regional values of fractal dimension ( ), computed using a box-counting algorithm developed in-house.
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