Dose effect and duration of action of liposomal bupivacaine administered as a perineural analgesic in a reversible and adjustable frog-pressure model of equine lameness.

Objective: To determine the dose effect of peri-neural liposomal bupivacaine (LB) in an induced forelimb lameness model.

Animals: 12 clinically normal adult horses.

Methods: A randomized cross-over design was performed with 1 limb receiving saline and the other LB: low dose (6), high dose (6).