Dopamine or norepinephrine for sepsis-related hypotension in preterm infants: a retrospective cohort study.

Unlabelled: The purpose of this study is to compare the clinical effectiveness of dopamine (DA) versus norepinephrine (NE) as first-line therapy for sepsis-related hypotension in preterm infants. This is a retrospective cohort study over 10 years at two tertiary neonatal units. Preterm infants born < 35 weeks post-menstrual age (PMA), who received DA or NE as primary therapy for hypotension during sepsis, defined as culture-positive or culture-negative infections or necrotizing enterocolitis (NEC), were included.

Validity of the vasoactive-inotropic score in preterm neonates receiving cardioactive therapies.

Background: Vasoactive-Inotropic Score (VIS) is a weighted sum of various vasopressors and inotropes; its utility among preterm neonates is understudied.

Objective: To investigate the association between maximum VIS (VIS) during the first 12, 24 and 48 h of treatment among preterm neonates who received vasopressors/inotropes, and the composite outcome of death/severe neuroinjury (sNI).

Methods: Retrospective cohort study, over 6-years, including neonates <35 weeks gestational age (GA).