Publications by authors named "Gabriella R Seidler"
Chiropractic spinal manipulation therapy (CSMT) of the cervical spine has been reported to cause mechanical dural injuries that result in cerebrospinal fluid (CSF) leaks. We present a case of symptomatic intracranial hypotension after isolated thoracic CSMT. Initial imaging was unable to definitively localize the CSF leak, but dynamic imaging was able to better identify the defect.
View Article and Find Full Text PDFImpact of Neurodevelopmental Disorders on Bowel Management Outcomes in Children with Functional Constipation.
J Pediatr Gastroenterol Nutr
September 2022
Objectives: Patients experiencing functional constipation (FC) can participate in structured bowel management programs (BMPs) to manage constipation or fecal incontinence when standard management fails. We sought to evaluate the efficacy of BMPs for children with FC with and without neurodevelopmental disorders.
Methods: We performed a retrospective review of children with FC who participated in our BMP from 2014 to 2021.
Chagas disease, caused by the intracellular protozoan parasite , is a public health problem affecting 6 to 8 million people, mainly in Latin America. The role of microRNAs in the pathogenesis of Chagas disease has not been well described. Here, we investigate the role of microRNA-155 (miR-155), a proinflammatory host innate immune regulator responsible for T helper type 1 and type 17 (Th1 and Th17) development and macrophage responses during infection.
View Article and Find Full Text PDFArticle Synopsis
- New treatments for leishmaniasis are needed due to the toxicity and poor compliance associated with current medications like antimonials.
- This study evaluated the effectiveness of oral ibrutinib in treating visceral leishmaniasis (VL), showing it was more effective than the standard treatment.
- Ibrutinib enhanced the immune response by increasing specific immune cell activity and cytokine production, suggesting it could be a promising new treatment for VL.