Complex analysis of multiple single nucleotide polymorphisms as putative risk factors of tooth agenesis in the Hungarian population.

Objectives: The role was studied of multiple single nucleotide polymorphisms in tooth agenesis in the Hungarian population using a complex approach.

Methods: Eight SNPs, PAX9 -912 C/T, PAX9 -1031 A/G, MSX1 3755 A/G, FGFR1 T/C rs881301, IRF6 T/C rs764093, AXIN2-8150 A/G, AXIN2-8434 A/G and AXIN2-30224 C/T, were studied in 192 hypodontia and 17 oligodontia cases and in 260 healthy volunteers. Case-control analysis was performed to test both allelic and genotypic associations as well as associations at the level of haplotypes.

[Treatment options of missing teeth resulting from hypodontia. Literature overview II].

Congenital hypodontia may cause serious emotional and physical problems which can become particularly grave during adolescence. This article highlights the importance of early diagnosis and the prevention of the progress of the state, and discusses a variety of definitive treatment plans. The aim of restorative dentistry is to restore function, improve appearance and prevent complications caused by hypodontia.

[Treatment options of missing teeth resulting from hypodontia. Literature overview I].

Nowadays there is an increased need to identify genetic polimorphisms, the underlying genetic factors of hypodontia. This article aims to describe the genetic components of hypodontia, the most frequent congenital tooth development disorder, as well as its interdisciplinary treatment. Congenitally missing teeth may cause serious emotional and physical problems particularly during adolescence.

[Isolating, culturing and characterizing stem cells of human dental pulp origin].

Evidence has been accumulating for the presence of stem cells in dental tissues. The authors' studies aimed to produce primary culture from human dental pulp. Furthermore, they wanted to identify clonogenic cells with progenitor properties in these cultures, and to characterize their proliferative capacity.