Identifying and categorizing compounds that reduce corneal transforming growth factor beta induced protein levels: a scoping review.

Introduction: Transforming growth factor beta induced () gene mutations have been reported as the cause of a group of genetically inherited, visually debilitating, corneal dystrophies (CD). A scoping literature review to identify and categorize compounds that inhibit corneal expression and/or promote TGFBIp degradation was performed. Emphasis was given to their potential to be used as a cost-effective approach via drug repurposing.

Maltese Allelic Variants in Corneal Dystrophy Genes in a Worldwide Setting.

Introduction: This study aimed to establish which worldwide population cohorts have a genetic make-up closest to that of a large sample of the Maltese population with regard to corneal dystrophy (CD) genes.

Methods: Single nucleotide polymorphisms (SNPs) in the Maltese cohort were compared with worldwide cohorts. Fixation index (F) values were calculated to evaluate population differentiation.