Background: We present the results of an academic phase 2 study on imatinib plus everolimus in patients who have progressive advanced chordoma.
Methods: In January 2011, 43 adult chordoma patients were enrolled in the study and received imatinib 400 mg/day and everolimus 2.5 mg/day until progression or limiting toxicity.
Purpose: The incidence and management of antitumoral compound extravasation that occurred in our medical day hospital unit were registered in a 10-year period.
Methods: A total of 114 episodes were consecutively recorded out of an estimated number of 211,948 administrations performed (0.05%).