Publications by authors named "Gabriella Alves Quixabeira Oliveira"
Sociodemographic and clinical characterization of cases of 1,103 non-syndromic and 66 syndromic odontogenic keratocyst: a Brazilian multicenter study.
Clin Oral Investig
November 2023
Article Synopsis
- This multicenter study analyzed 1,341 cases of odontogenic keratocysts from 1,169 patients to explore differences between non-syndromic and syndromic cases, including recurrence rates.
- The study found that non-syndromic cases were more common, with the posterior mandible being the most affected site, and noted that most lesions were unilocular and asymptomatic.
- Conservative treatment was the most frequently used, and recurrences were rare; the study highlighted that clinical features could vary significantly between syndromic and non-syndromic patients.
Objective: Salivary gland tumors (SGT) are a diverse group of uncommon neoplasms that are rare in pediatric patients. This study aimed to characterize the clinicopathological profile of pediatric patients affected by SGT from a large case series derived from an international group of academic centers.
Study Design: A retrospective analysis of pediatric patients with SGT (0-19 years old) diagnosed between 2000 and 2021 from Brazil, South Africa, and the United Kingdom was performed.
Objectives: The objective of the present study was to investigate the expression of immune checkpoints (PD-L1, PD-L2, PD-1 and CTLA-4), immune inhibitory molecule HLA-G, markers of tumor-infiltrating lymphocytes (TIL) and dendritic cells (DC), as well as its association with clinicopathological features of adenoid cystic carcinomas (ACC) of the salivary glands.
Materials And Methods: Thirty-six samples from patients with ACC were analyzed immunohistochemically for the expression of PD-L1, PD-L2, PD-1, CTLA-4, HLA-G, CD8, GrB, CD1a and CD83. Positivity of HLA-G, PD-L1 and PD-L2 expression was defined by cut-offs values.