Publications by authors named "Gabriele Starker"
PKC-alpha modulates TGF-beta signaling and impairs podocyte survival.
Cell Physiol Biochem
February 2010
Article Synopsis
- The study investigates how the protein PKC-alpha (PKCalpha) affects podocyte cell survival when stimulated by TGF-beta, a factor involved in glomerular diseases.
- Researchers created podocyte cell lines lacking PKCalpha to analyze changes in cell survival and apoptosis signaling, observing distinct differences in signaling pathways compared to normal cells.
- The findings suggest that PKCalpha plays a crucial role in modulating the cell's response to TGF-beta, indicating that targeting PKCalpha could be a promising approach for protecting podocytes from damage in kidney diseases.