Publications by authors named "Gabriele Schwarz"
Article Synopsis
- The study aimed to understand ICU admission preferences among patients aged 80 and older, as well as how well their next-of-kin could predict these preferences.
- It involved surveying 202 outpatients regarding their ICU preferences in hypothetical critical illness scenarios, revealing that opinions on ICU admission were nearly evenly split, with many older patients choosing not to participate in the decision-making process.
- Next-of-kins showed weak agreement with the patients' true preferences, agreeing 52% of the time, but they were significantly more aligned with their own preferences at 79%, indicating a disconnect between older patients' wishes and their family's understanding.
Objectives: To conduct a systematic review of mortality and factors independently associated with mortality in older patients admitted to ICU.
Data Sources: MEDLINE via PubMed, EMBASE, the Cochrane Library, and references of included studies.
Study Selection: Two reviewers independently selected studies conducted after 2000 evaluating mortality of older patients (≥ 75 yr old) admitted to ICU.
Background According to Good Clinical Practice, clinical trials must protect rights and safety of patients and make sure that the trial results are valid and interpretable. Monitoring on-site has an important role in achieving these objectives; it controls trial conduct at trial sites and informs the sponsor on systematic problems. In the past, extensive on-site monitoring with a particular focus on formal source data verification often lost sight of systematic problems in study procedures that endanger Good Clinical Practice objectives.
View Article and Find Full Text PDFBackground: The concept of risk assessment for clinical trials has been discussed before, but no comprehensive structured procedure leading to risk-adapted quality management has been published so far. Such a procedure is of particular interest for noncommercial trials in order to optimally use the sparse resources.
Purpose: To provide a structured procedure for risk analysis in clinical trials.
Erythrokeratodermia variabilis (EKV) is a rare autosomal dominant human genodermatosis. Its clinical appearance varies from transient, fast moving erythemas to persistent brown hyperkeratoses. So far, several mutations in the Cx31 or Cx30.
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