Polydopamine Nanoparticles as an Organic and Biodegradable Multitasking Tool for Neuroprotection and Remote Neuronal Stimulation.

Oxidative stress represents a common issue in most neurological diseases, causing severe impairments of neuronal cell physiological activity that ultimately lead to neuron loss of function and cellular death. In this work, lipid-coated polydopamine nanoparticles (L-PDNPs) are proposed both as antioxidant and neuroprotective agents, and as a photothermal conversion platform able to stimulate neuronal activity. L-PDNPs showed the ability to counteract reactive oxygen species (ROS) accumulation in differentiated SH-SY5Y, prevented mitochondrial ROS-induced dysfunctions and stimulated neurite outgrowth.

Impact of pump-signal overlap in S+C+L band discrete Raman amplifiers.

We experimentally investigate the impact of pump-signal overlap in ultra-wideband (>13THz) Raman amplifiers and measure the transmission penalty on 30GBaud PM-QPSK signals due to adjacent Raman pumps in a 15dB gain, 150nm (∼18.8THz) S+C+L-band discrete Raman amplifier. We present an efficient numerical model to predict the performance penalty induced by crosstalk from Rayleigh backscattered light from backward-propagating Raman pumps showing good agreement with the experimental results.

Healthspan Enhancement by Olive Polyphenols in Wild Type and Parkinson's Models.

Parkinson's disease (PD) is the second most prevalent late-age onset neurodegenerative disorder, affecting 1% of the population after the age of about 60 years old and 4% of those over 80 years old, causing motor impairments and cognitive dysfunction. Increasing evidence indicates that Mediterranean diet (MD) exerts beneficial effects in maintaining health, especially during ageing and by the prevention of neurodegenerative disorders. In this regard, olive oil and its biophenolic constituents like hydroxytyrosol (HT) have received growing attention in the past years.

Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in .

Numerous studies highlighted the beneficial effects of the Mediterranean diet (MD) in maintaining health, especially during ageing. Even neurodegeneration, which is part of the natural ageing process, as well as the foundation of ageing-related neurodegenerative disorders like Alzheimer's and Parkinson's disease (PD), was successfully targeted by MD. In this regard, olive oil and its polyphenolic constituents have received increasing attention in the last years.

Statistical quantification of nonlinear interference noise components in coherent systems.

We present and validate a statistical method able to separate nonlinear interference noise (NLIN) into a residual Gaussian (ResN) and a phase noise (NLPN) component. We take into account the interaction of the NLIN with the receiver's DSP, mainly through carrier phase recovery (CPR), by considering the amount of correlation of the NLPN component. This allows obtaining in a straightforward way an accurate prediction of the achievable post-DSP transmission performance.

Di (2-ethylhexyl) phthalate targets the thioredoxin system and the oxidative branch of the pentose phosphate pathway in liver of Balb/c mice.

Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer that gives flexibility to various polyvinyl chloride products. It is a pollutant easily released into the environment and can cause many adverse effects to living organisms including hepatotoxicity. The thioredoxin system is a determining factor in the redox balance maintaining in the liver, which is a vulnerable tissue of reactive oxygen species overproduction because of its high energy needs.

CeO Nanoparticles-Loaded pH-Responsive Microparticles with Antitumoral Properties as Therapeutic Modulators for Osteosarcoma.

Osteosarcoma is an aggressive form of bone cancer mostly affecting young people. To date, the most effective strategy for the treatment of osteosarcoma is the surgical removal of the tumor with or without combinational chemotherapy. In this study, we present the development of a pH-sensitive drug-delivery system in the form of microparticles, with increased chemotherapeutic action against the osteosarcoma cell line SAOS-2, and with reduced toxicity against the heart myoblastic cell line H9C2.

Determination of blood lactate training zone boundaries with rating of perceived exertion in runners.

This study aimed to determine the rating of perceived exertion (RPE) values corresponding to the blood lactate concentration (BLC) training zone boundaries (2 and 4 mmol·L) in moderately trained runners using the Borg CR-10 scale. Moderately trained runners (n = 95) performed a submaximal incremental test on a treadmill, recording BLC and RPE at every stage. Simple linear regression analysis was used to determine the RPE values corresponding to the BLC training zone boundaries, which revealed that RPE was significantly and strongly correlated with BLC (r = 0.

Energetics of running in top-level marathon runners from Kenya.

On ten top-level Kenyan marathon runners (KA) plus nine European controls (EC, equivalent to KA), we measured maximal oxygen consumption (VO2max) and the energy cost of running (Cr) on track during training camps at moderate altitude, to better understand the KA dominance in the marathon. At each incremental running speed, steady-state oxygen consumption (VO2) was measured by telemetric metabolic cart, and lactate by electro-enzymatic method. The speed requiring VO2 = VO2max provided the maximal aerobic velocity (νmax).