Prevalence and risk factors for congenital diaphragmatic hernia: A global view.

Purpose: To determine the global prevalence for congenital diaphragmatic hernia (CDH) and identify CDH-related risk factors.

Methods: Using a defined strategy, a systematic review of the literature was conducted according to PRISMA guidelines, searching for population-based epidemiological studies to evaluate the prevalence of CDH globally and per country. Studies containing overlapping populations or timeframes were excluded.

Neurodevelopmental impairment in children with congenital diaphragmatic hernia: Not an uncommon complication for survivors.

Purpose: To evaluate neurodevelopmental impairment (NDI) in children born with congenital diaphragmatic hernia (CDH).

Methods: Using a defined search strategy, a systematic review was conducted to define the incidence and types of NDI, to report abnormal neuroimaging findings and to evaluate possible NDI predictors. A meta-analysis was performed on comparative studies reporting risk factors for NDI, using RevMan 5.

Autosomal dominant tubulointerstitial kidney disease caused by uromodulin mutations: seek and you will find.

Background: Uromodulin (UMOD)-associated kidney disease belongs to the group of autosomal dominant interstitial kidney diseases and is caused by mutations in the UMOD gene. Affected patients present with hyperuricemia, gout, and progressive renal failure. The disease is thought to be very rare but is probably underdiagnosed.