Publications by authors named "Gabriele Lubatti"
Article Synopsis
- Single-cell genomics enables the identification of cell types based on their molecular profiles, especially helping to find novel and rare cell types through RNA sequencing.
- The new tool CIARA (Cluster Independent Algorithm for the identification of markers of RAre cell types) is designed to identify genes that could serve as markers for these rare cell types, addressing a limitation of traditional clustering methods.
- CIARA has proven to outperform existing techniques for detecting rare cell types and can be applied to various single-cell data types, with user-friendly implementations available in R and Python.
Article Synopsis
- Cell competition is a process that helps get rid of weak or unhealthy cells in the body, especially during early development in mice.
- Researchers found that cells with problems in their mitochondria (which help produce energy) are the ones mostly eliminated during this process.
- They discovered that even small changes in mitochondrial DNA can cause these cells to be removed, making sure that the stronger, healthier cells stay to support proper development.
Totipotent cells hold enormous potential for regenerative medicine. Thus, the development of cellular models recapitulating totipotent-like features is of paramount importance. Cells resembling the totipotent cells of early embryos arise spontaneously in mouse embryonic stem (ES) cell cultures.
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