Publications by authors named "Gabriele Husmann"
Article Synopsis
- Treatment concepts in oncology are becoming personalized and diverse, requiring continuous monitoring of patient care through real-world data, which the DKTK's Clinical Communication Platform (CCP) facilitates.
- The CCP connects 14 cancer centers and analyzes data from over 600,000 patients, focusing on diverse demographic details, diagnoses, treatment responses, and extensive biosample collections.
- Through its sizable and detailed dataset, the cohort aids translational cancer research, enhances understanding of various cancers, and supports clinical trial design and evaluation in real-world settings.
Article Synopsis
- The study analyzed real-world data from 145 patients with stage IV somatostatin-neuroendocrine tumors (siNET) to compare the survival outcomes based on different treatment regimens.
- Survival rates showed that all patients had a high one-year overall survival (OS) rate of 93.8%, but treatment regimens like chemotherapy and multimodal approaches did not significantly enhance survival compared to somatostatin analogues (SSA) alone.
- The resection of the primary tumor greatly improved the five-year survival rates, indicating its crucial role in patient outcomes.
Patients with neuroendocrine tumors (NET) often go through a long phase between onset of symptoms and initial diagnosis.Assessment of time to diagnosis and pre-clinical pathway in patients with gastroenteropancreatic NET (GEP-NET) with regard to metastases and symptoms.Retrospective analysis of patients with GEP-NET at a tertiary referral center from 1984 to 2019; inclusion criteria: Patients ≥18 years, diagnosis of GEP-NET; statistical analysis using non-parametrical methods.
View Article and Find Full Text PDFA powerful hospital information system (HIS) contains information about diagnostic and disease data of all patients in a hospital. In the university hospital in Frankfurt / Main Germany more than 80% of all wards are completely "paperless". But the identification of patients for clinical trials is very difficult.
View Article and Find Full Text PDFIT behind a platform for Translational Cancer Research - concept and objectives.
Stud Health Technol Inform
January 2013
The German Consortium for Translational Cancer Research (DKTK) and the Rhine-Main Translational Cancer Research Network (RM-TCRN) are designed to exploit large population cohorts of cancer patients for the purpose of bio-banking, clinical trials, and clinical cancer registration. Hence, the success of these platforms is heavily dependent on the close interlinking of clinical data from cancer patients, information from study registries, and data from bio-banking systems of different laboratories and scientific institutions. This article referring to the poster discusses the main challenges of the platforms from an information technology point of view, legal and data security issues, and outlines an integrative IT-concept concerning a decentralized, distributed search approach where data management and search is in compliance with existing legislative rules.
View Article and Find Full Text PDFAim: To investigate the cancer risk among residents of Rhineland-Palatinate winegrowing communities in an ecological study.
Methods: On the basis of the Rhineland-Palatinate cancer-registry, we calculated age-adjusted incidence rate ratios for communities with a medium area under wine cultivation (>5 to 20 percent) and a large area under wine cultivation (>20 percent) in comparison with communities with a small area under wine cultivation (>0 to 5 percent). In a side analysis, standardized cancer incidence ratios (SIR) were computed separately for winegrowing communities with small, medium and large area under wine cultivation using estimated German incidence rates as reference.