Publications by authors named "Gabriele Gasparini"

Coronary dissection is a potential occurrence after lesion preparation for percutaneous coronary intervention (PCI). Unlike stents, drug-coated balloons (DCB) do not allow to cover dissections, thus demanding an assessment of their safety in this setting. The aim of this study was to evaluate incidence, predictors, and clinical outcomes of dissections occurring with DCB-based PCI for de novo coronary artery disease (CAD).

View Article and Find Full Text PDF

Background: Advancing the retrograde microcatheter (MC) into the antegrade guide catheter during retrograde chronic total occlusion (CTO) percutaneous coronary intervention (PCI) can be challenging or impossible, preventing guidewire externalization.

Objectives: To detail and evaluate all the techniques focused on wiring to achieve intubation of the distal tip of a microcatheter, balloon, or stent with an antegrade or retrograde guidewire, aiming to reduce complications by minimizing tension on fragile collaterals during externalization and enabling rapid antegrade conversion in various clinical scenarios.

Methods: We describe the two main techniques, tip-in and rendezvous, and their derivatives such a facilitated tip-in, manual MC-tip modification, tip-in the balloon, tip-in the stent, deep dive rendezvous, catch-it and antegrade microcatheter probing.

View Article and Find Full Text PDF

Coronary chronic total occlusions (CTO) are frequently identified during coronary angiography and remain the most challenging subset of coronary artery lesions to treat; however, advancements in techniques and materials have greatly improved success rates. Various crossing algorithms have been developed to standardise the approach to CTO interventions based on angiographic criteria. Antegrade wiring is typically the initial strategy of choice, particularly in cases of short and straight CTOs with tapered proximal cap.

View Article and Find Full Text PDF
Article Synopsis
  • The CTO-ARC identified the need for standardized definitions in chronic total occlusion (CTO) procedures to avoid bias in attributing complications to different crossing strategies.
  • A study analyzed data from 8,673 patients in the European Registry of Chronic Total Occlusions, finding that the antegrade approach was used in 79.2% of cases, while retrograde was used in 20.8%.
  • Results showed that alternative antegrade crossing had lower technical success rates and higher complication rates compared to true antegrade and retrograde methods, though it was primarily used as a rescue strategy in most instances.
View Article and Find Full Text PDF
Article Synopsis
  • Coronary artery dissections occur when there is a tear in the vessel lining, leading to blood pooling and formation of an intramural hematoma, which can obstruct blood flow.
  • A new method called the "Cuttering Technique" was tested on seven patients to improve drainage of the hematoma and restore blood flow by creating tears between the false and true lumen of the artery.
  • The results showed that five out of seven patients achieved significant improvement in blood flow, indicating that the "Cuttering Technique" is an effective way to manage complications from intramural hematomas.
View Article and Find Full Text PDF
Article Synopsis
  • Bifurcation involvement in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is a significant challenge, but this factor hasn't been widely studied or included in existing scoring systems.
  • An analysis of 3,948 CTO-PCI procedures from 92 European centers revealed that 33% of these cases involved bifurcation lesions, which were generally more complex and required more sophisticated devices, resulting in higher radiation and contrast exposure.
  • Despite comparable overall technical success rates between bifurcation and non-bifurcation lesions, bifurcation lesions located within the CTO segment faced significantly lower success rates, making it crucial to consider their presence in future PCI assessments.
View Article and Find Full Text PDF

Background: Percutaneous coronary interventions (PCI) of chronic total occlusions (CTO) have reached high procedural success rates thanks to dedicated equipment, evolving techniques, and worldwide adoption of state-of-the-art crossing algorithms.

Aims: We report the contemporary results of CTO PCIs performed by a large European community of experienced interventionalists. Furthermore, we investigated the impact of different risk factors for procedural major adverse cardiac and cerebrovascular events (MACCE) and trends of employment of specific devices like dual lumen microcatheters, guiding catheter extensions, intravascular ultrasound and calcium-modifying tools.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to evaluate the feasibility of a virtual proctoring method using audio-video communication during complex cardiac procedures.
  • Nine patients received percutaneous coronary interventions with guidance from a remote expert, with no major complications reported during or after the procedures.
  • The results suggest that virtual proctoring is a safe and effective method, allowing for expert collaboration across distances, potentially enhancing the development of complex cardiac procedures in the future.
View Article and Find Full Text PDF

Background: Percutaneous treatment for ostial left circumflex artery (LCx) lesions is known to be associated with suboptimal results.

Aims: The present study aims to assess the procedural and long-term clinical outcomes of percutaneous coronary intervention (PCI) for de novo ostial LCx lesions overall and according to the coronary revascularization strategy.

Methods: Consecutive patients undergoing PCI with second generation drug eluting stents or drug coated balloons for de novo ostial LCx lesions in three high-volume Italian centers between 2012 and 2021 were retrospectively evaluated.

View Article and Find Full Text PDF
Article Synopsis
  • Drug-coated balloons (DCB) show promise for treating de novo lesions in large vessels, but there is limited evidence on their effectiveness compared to drug-eluting stents (DES).
  • A study comparing 147 patients treated with DCB to 701 patients receiving DES found no significant difference in target lesion failure rates after 2 years.
  • After adjusting for patient characteristics, DCB treatment was associated with a significantly lower risk of target lesion failure, primarily due to reduced need for revascularization.
View Article and Find Full Text PDF

Despite improvements in current devices and techniques for complex chronic total occlusion (CTO) percutaneous coronary intervention (PCI), procedural complications, including coronary perforation, still occur and could be life-threatening. A patient with a history of multivessel coronary artery disease and a CTO of the right coronary artery (RCA) underwent successful retrograde crossing of an RCA CTO. After wiring the CTO body and lesion dilatation, a drug-eluting stent was implanted in the distal RCA toward the posterior descending artery.

View Article and Find Full Text PDF

The use of coils is fundamental in interventional cardiology and can be lifesaving in selected settings. Coils are classified by their materials into bare metal, fiber coated, and hydrogel coated, or by the deliverability method into, pushable or detachable coils. Coils are delivered through microcatheters and the choice of coil size is important to ensure compatibility with the inner diameter of the delivery catheter, firstly to be able to deliver and secondly to prevent the coil from being stuck and damaged.

View Article and Find Full Text PDF

Background: The recent development and widespread adoption of antegrade dissection re-entry (ADR) techniques have been underlined as one of the antegrade strategies in all worldwide CTO consensus documents. However, historical wire-based ADR experience has suffered from disappointing long-term outcomes.

Aims: Compare technical success, procedural success, and long-term outcome of patients who underwent wire-based ADR technique versus antegrade wiring (AW).

View Article and Find Full Text PDF

Guiding catheter extensions (GCEs) have become indispensable tools in the modern approach to percutaneous coronary intervention (PCI). The support offered during complex PCI of uncrossable, or tortuous lesions is particularly valuable in the setting of chronic total occlusions (CTO), both for conventional anterograde wire escalation and for anterograde or retrograde dissection and re-entry techniques. This EuroCTO consensus document describes the use of GCE during CTO recanalization and provides a practical guide to anatomies and techniques in which these devices are applicable.

View Article and Find Full Text PDF

Background: In the setting of coronary artery dissection, both spontaneous and iatrogenic, fixing the intimal tear, usually with stent implantation, can be extremely challenging if the distal wire position has been lost. Common complications are mainly related to the inadvertent subintimal tracking of the guidewire while attempting to gain the distal true lumen.

Aims: To report the registry results of using the SUOH 0.

View Article and Find Full Text PDF
Article Synopsis
  • Outcomes for chronic total occlusion percutaneous coronary intervention (PCI) have significantly improved over the past ten years, with a focus on enhancing safety during procedures.
  • Vascular access site bleeding is a common complication that can occur during these procedures.
  • The review discusses various strategies that have been developed to minimize vascular access site complications in chronic total occlusion PCI.
View Article and Find Full Text PDF

Chronic total occlusion (CTO) interventions are among the most complex procedures within the panorama of percutaneous coronary intervention (PCI). Awareness of potential complications, adequate procedural planning in order to avoid them, and prompt recognition and management should any occur are at the cornerstone of a successful CTO programme. Complications can be acute or late after the procedure and can be cardiac or non-cardiac.

View Article and Find Full Text PDF

Background: Gender-specific data addressing percutaneous coronary intervention (PCI) of chronic total occlusion (CTO) in female patients are scarce and based on small sample size studies.

Aims: We aimed to analyze gender-differences regarding in-hospital clinical outcomes after CTO-PCI.

Methods: Data from 35,449 patients enrolled in the prospective European Registry of CTOs were analyzed.

View Article and Find Full Text PDF

Background: Chronic total occlusion (CTO) revascularization is a major source of radiation for both patients and physicians. Therefore, efforts to minimize radiation during CTO percutaneous coronary intervention (PCI) are highly encouraged.

Aims: To evaluate the impact of an Ultra Low fluoroscopic Dose Protocol (ULDP), based on 3.

View Article and Find Full Text PDF