Adenosine A and dopamine D receptor interaction controls fatigue resistance.

Caffeine and the selective A receptor antagonist SCH58261 both have ergogenic properties, effectively reducing fatigue and enhancing exercise capacity. This study investigates in male Swiss mice the interaction between adenosine A receptors and dopamine D receptors controlling central fatigue, with a focus on the striatum where these receptors are most abundant. We employed DPCPX and SCH58261 to antagonize A and A receptors, caffeine as a non-competitive antagonist for both receptors, and haloperidol as a D receptor antagonist; all compounds were tested upon systemic application and caffeine and SCH58261 were also directly applied in the striatum.