Publications by authors named "Gabriela Zuleger"
Neoantigen-specific T cell receptors (neoTCRs) promise safe, personalized anti-tumor immunotherapy. However, detailed assessment of neoTCR-characteristics affecting therapeutic efficacy is mostly missing. Previously, we identified diverse neoTCRs restricted to different neoantigens in a melanoma patient.
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- Systemic pan-tumor analyses help uncover key features related to cancer immune response and patient outcomes across different tumor types.
- A study involving 32 patients and 25 tumor types employed multi-omics data to discover various tumor-specific neoantigens using an optimized computational pipeline that integrates DNA/RNA sequencing and mass spectrometry.
- The research highlights the significance of RNA data in identifying potential neoantigens, revealing 32 promising candidates linked to RNA-identified variants, thereby emphasizing the need for further exploration in this area.