Publications by authors named "Gabriela Yuri"
Article Synopsis
- Aging and obesity lead to insulin resistance and inflammation, with mechanisms involving impaired glucose uptake and the NF-κB pathway; elevated palmitic acid (PA) in obesity exacerbates these issues.* -
- In laboratory tests on human adipocytes, different concentrations of Lampaya (HEL) were shown to have no toxic effects, while PA reduced insulin signaling and glucose uptake; HEL, when co-treated with PA, improved these markers.* -
- The study found that HEL helps mitigate the negative effects of PA on insulin signaling by increasing phospho-Akt and glucose uptake, while also reducing inflammatory markers like phospho-NF-κB and phospho-AS160.*
Elevated circulating fatty acids in obesity may induce hepatic steatosis, leading to liver inflammation, fibrosis and nonalcoholic fatty liver disease (NAFLD). On the other hand, impaired communication between hepatocytes and adipose tissue (AT) in obesity influences adipose lipolysis and fibrosis, negatively affecting metabolic function. Infusions of Lampaya medicinalis Phil.
View Article and Find Full Text PDFAutophagy is upregulated in adipose tissue (AT) from people with obesity. We showed that activation of the calcium-sensing receptor (CaSR) elevates proinflammatory cytokines through autophagy in preadipocytes. Our aim is to understand the role of CaSR on autophagy in AT from humans with obesity.
View Article and Find Full Text PDF