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Publications by authors named "Gabriela Warpsinski"

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Nrf2-regulated redox signaling in brain endothelial cells adapted to physiological oxygen levels: Consequences for sulforaphane mediated protection against hypoxia-reoxygenation.
Gabriela Warpsinski Matthew J Smith Salil Srivastava Thomas P Keeley Richard C M Siow

Redox Biol

October 2020

Ischemic stroke is associated with a surge in reactive oxygen species generation during reperfusion. The narrow therapeutic window for the delivery of intravenous thrombolysis and endovascular thrombectomy limits therapeutic options for patients. Thus, understanding the mechanisms regulating neurovascular redox defenses are key for improved clinical translation.

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Synopsis of recent research by authors named "Gabriela Warpsinski"

  • - Gabriela Warpsinski's recent research primarily focuses on the mechanisms of redox signaling in brain endothelial cells, particularly in relation to ischemic stroke and the effects of physiological oxygen levels.
  • - In her 2020 article published in "Redox Biol," she investigates how Nrf2 regulates redox defense mechanisms, which are critical during hypoxia-reoxygenation events that cause oxidative stress.
  • - The findings emphasize the potential of sulforaphane as a neuroprotective agent by enhancing the brain’s redox defenses, highlighting the need for further exploration of therapeutic strategies targeting redox signaling in stroke management.

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