Publications by authors named "Gabriela Santos de Jesus"
Prospective Randomized Phase 2 Trial of Hypofractionated Stereotactic Radiation Therapy of 25 Gy in 5 Fractions Compared With 35 Gy in 5 Fractions in the Reirradiation of Recurrent Glioblastoma.
Andre Tsin Chih Chen Alexandre Ruggieri Serante Aline Sgnolf Ayres Juliana Ono Tonaki Raquel Andrade Moreno Gabriela Reis Dos Santos de Jesus
Int J Radiat Oncol Biol Phys
July 2024
Article Synopsis
- The study aimed to evaluate if reirradiation of recurrent glioblastoma with higher doses of hypofractionated stereotactic radiation therapy (HSRT) would improve patient outcomes compared to a lower dose while keeping side effects manageable.
- A randomized trial involved 40 patients who were assigned to receive either 25 Gy in 5 fractions or 35 Gy in 5 fractions. Results showed no significant difference in progression-free survival (PFS) or overall survival (OS) between the two groups.
- Despite a slight numerical increase in severe necrosis in the higher dose group, it was concluded that the lower dose (25 Gy/5 fx) should be the standard for HSRT due to similar effectiveness and potentially lower toxicity
Background: Reducing poverty and improving access to health care are two of the most effective actions to decrease maternal mortality, and conditional cash transfer (CCT) programmes act on both. The aim of this study was to evaluate the effects of one of the world's largest CCT (the Brazilian Bolsa Familia Programme (BFP)) on maternal mortality during a period of 11 years.
Methods: The study had an ecological longitudinal design and used all 2548 Brazilian municipalities with vital statistics of adequate quality during 2004-2014.