Publications by authors named "Gabriela S Keller"
The involvement of neuroinflammation in an animal model of dementia and depression.
Prog Neuropsychopharmacol Biol Psychiatry
July 2024
Alzheimer's disease (AD) and depression are inflammatory pathologies, leading to increased inflammatory response and neurotoxicity. Therefore, this study aimed to evaluate the effect of the treatment with fluoxetine and/or galantamine and/or donepezil on the levels of proinflammatory and anti-inflammatory cytokines in a mixed animal model of depression and dementia. Adult male Wistar rats underwent chronic mild stress (CMS) protocol for 40 days and were subjected to stereotaxic surgery for intra-hippocampal administration of amyloid-beta (Aꞵ) peptide or artificial cerebrospinal fluid (ACSF) to mimic the dementia animal model.
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- Older adults, especially those aged 80 and above, face a growing risk of cognitive impairment, which this study aimed to assess in community-dwelling seniors.
- The research involved 165 participants who were interviewed using health and demographic questionnaires, with results indicating that 35.2% exhibited poor cognitive performance as measured by the Mini-Mental State Examination (MMSE).
- Key factors associated with cognitive impairment included body mass index (BMI), income level, functional disability, and anxiety, although the study has limitations like its cross-sectional nature and a small sample size.
Article Synopsis
- Evidence suggests that diet and nutrients can enhance mental health and aid in treating psychiatric disorders.
- Resveratrol, a compound found in certain foods, shows promise in helping conditions like major depression, bipolar disorder, Alzheimer's, and autism.
- The review examines both animal and human studies to explore how resveratrol functions through pathways that manage oxidative stress, inflammation, and cell death.
Vitamin D3 deficiency is associated with an increased risk of dementia. An association between vitamin D3 deficiency and subjective cognitive complaints in geriatric patients has been previously reported. This study aimed to evaluate the effects of two doses of vitamin D3 on spatial memory (using the Radial Maze) and cytokine levels [tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and interleukin-10 (IL-10)] on 2-, 6-, 13-, 22-, and 31-month-old male Wistar rats.
View Article and Find Full Text PDFThe human lifespan is increasing, and mankind is aging. It is estimated that, until the year 2050, this population worldwide will reach 22% of the total world population. Along with aging, the human immunologic system changes, a process called immunosenescence or even inflammaging.
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